Brd4 modulates metabolic endotoxemia-induced inflammation by regulating colonic macrophage infiltration in high-fat diet-fed mice

Brd4 modulates metabolic endotoxemia-induced inflammation by regulating colonic macrophage infiltration in high-fat diet-fed mice

Abstract High-fat diet (HFD) induces low-grade chronic inflammation, contributing to obesity and insulin resistance. However, the precise mechanisms triggering obesity-associated metabolic inflammation remain elusive. In this study, we identified epigenetic factor Brd4 as a key player in this proces...

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Main Authors: Jinfeng Hu, Guo Li, Xiaoxin He, Xuming Gao, Dun Pan, Xingchen Dong, Wentao Huang, Funan Qiu, Lin-Feng Chen, Xiangming Hu
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07437-2
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https://doi.org/10.1038/s42003-024-07437-2

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