Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potency

Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potency

Antibody drugs targeting single inflammatory cytokines have revolutionized the treatment of immune-mediated inflammatory diseases. To investigate whether dual targeting interleukin-17 (IL-17) and IL-36 enhances anti-inflammatory activity, bispecific Ab HB0043 was generated by linking the single chai...

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Main Authors: Xiaojuan Ma, Shuang Zhang, Xiaochen Ren, Yujie Feng, Hui Li, Shi Chen, Jingen Xu, Yanting Wang, Guo-yuan Peng, Qingran Yan, Huifeng Jia, Simin Xia, Xiaopei Cui, Xiaofang Chen, Xianfei Pan, Shaojie Wang, Haijia Yu, Xiaoyue Wei, Mingwei Li, Bei Liu, Jingyue Xu, Qiaoxia Qian, Xiangyang Zhu, Yifan Zhan, Liangjing Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
bispecific antibody
IL-17A
IL-36R
skin inflammation
skin fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1434127/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1434127/full

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