Characterization of Pancreatic Infections in Patients with Severe Acute Pancreatitis: A Retrospective Study from 2019 to 2023
Yong Chen,1,* Qichao Cui,2,* Jin Cao,1 Qiuyue Wu,1 Peixuan Lu,1 Gang Li,3 Ning Sun1 1Department of Clinical Laboratory Science, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China; 2Department of Ultrasound Diagnosis, Jinli...
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Dove Medical Press
2025-01-01
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| Series: | Infection and Drug Resistance |
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| author | Chen Y Cui Q Cao J Wu Q Lu P Li G Sun N |
| author_facet | Chen Y Cui Q Cao J Wu Q Lu P Li G Sun N |
| author_sort | Chen Y |
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| description | Yong Chen,1,* Qichao Cui,2,* Jin Cao,1 Qiuyue Wu,1 Peixuan Lu,1 Gang Li,3 Ning Sun1 1Department of Clinical Laboratory Science, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China; 2Department of Ultrasound Diagnosis, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China; 3Department of Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gang Li; Ning Sun, Email nju8icu@126.com; steamsn@163.comObjective: This study investigated the distribution and changes in pancreatic infections among patients with acute pancreatitis (AP) from 2019 to 2023, while exploring the impact of multidrug-resistant bacterial infections on the prognosis of patients with poor outcomes.Methods: This study included patients diagnosed with SAP between 2019 and 2023 and collected the demographic and clinical characteristics of all participants. Based on routine clinical microbiological culture results, the distribution and drug resistance of pathogens associated with pancreatic infections were analyzed. Multivariable logistic regression was used to evaluate the association between multidrug-resistant organism (MDRO) infection and poor prognosis.Results: A total of 1586 pancreatic fluid specimens were analyzed and collected from 843 patients diagnosed with AP. The positive rate of the culture results was 81% (1280/1586), with the predominant pathogens identified as Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus faecium, and Acinetobacter baumannii complex. Of the 843 patients, 756 met the criteria, and the proportion of MDROs in pancreatic infections was 87.57% (662/756). Multivariate logistic regression analysis revealed that septic shock, acute kidney injury, and tracheostomy were associated with a poor prognosis, whereas ICU length of stay, infected pancreatic necrosis, and tracheostomy were associated with multidrug-resistant bacterial infections in patients with severe or critical AP.Conclusion: The proportion of MDRO infections in patients with severe or critical AP was notably high, primarily involving multidrug-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Septic shock, acute kidney injury, and tracheostomy have been identified as independent risk factors of poor prognosis in patients with severe or critical AP.Keywords: severe acute pancreatitis, pancreatic infection, microbiological profiles, multidrug-resistant organism, risk factor |
| format | Article |
| id | doaj-art-e233e9fcad0b42fc907b03efff91260b |
| institution | Kabale University |
| issn | 1178-6973 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Infection and Drug Resistance |
| spelling | doaj-art-e233e9fcad0b42fc907b03efff91260b2025-01-12T16:52:42ZengDove Medical PressInfection and Drug Resistance1178-69732025-01-01Volume 1819920799182Characterization of Pancreatic Infections in Patients with Severe Acute Pancreatitis: A Retrospective Study from 2019 to 2023Chen YCui QCao JWu QLu PLi GSun NYong Chen,1,* Qichao Cui,2,* Jin Cao,1 Qiuyue Wu,1 Peixuan Lu,1 Gang Li,3 Ning Sun1 1Department of Clinical Laboratory Science, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China; 2Department of Ultrasound Diagnosis, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China; 3Department of Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gang Li; Ning Sun, Email nju8icu@126.com; steamsn@163.comObjective: This study investigated the distribution and changes in pancreatic infections among patients with acute pancreatitis (AP) from 2019 to 2023, while exploring the impact of multidrug-resistant bacterial infections on the prognosis of patients with poor outcomes.Methods: This study included patients diagnosed with SAP between 2019 and 2023 and collected the demographic and clinical characteristics of all participants. Based on routine clinical microbiological culture results, the distribution and drug resistance of pathogens associated with pancreatic infections were analyzed. Multivariable logistic regression was used to evaluate the association between multidrug-resistant organism (MDRO) infection and poor prognosis.Results: A total of 1586 pancreatic fluid specimens were analyzed and collected from 843 patients diagnosed with AP. The positive rate of the culture results was 81% (1280/1586), with the predominant pathogens identified as Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus faecium, and Acinetobacter baumannii complex. Of the 843 patients, 756 met the criteria, and the proportion of MDROs in pancreatic infections was 87.57% (662/756). Multivariate logistic regression analysis revealed that septic shock, acute kidney injury, and tracheostomy were associated with a poor prognosis, whereas ICU length of stay, infected pancreatic necrosis, and tracheostomy were associated with multidrug-resistant bacterial infections in patients with severe or critical AP.Conclusion: The proportion of MDRO infections in patients with severe or critical AP was notably high, primarily involving multidrug-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Septic shock, acute kidney injury, and tracheostomy have been identified as independent risk factors of poor prognosis in patients with severe or critical AP.Keywords: severe acute pancreatitis, pancreatic infection, microbiological profiles, multidrug-resistant organism, risk factorhttps://www.dovepress.com/characterization-of-pancreatic-infections-in-patients-with-severe-acut-peer-reviewed-fulltext-article-IDRsevere acute pancreatitispancreatic infectionmicrobiological profilesmultidrug-resistant organismrisk factor |
| spellingShingle | Chen Y Cui Q Cao J Wu Q Lu P Li G Sun N Characterization of Pancreatic Infections in Patients with Severe Acute Pancreatitis: A Retrospective Study from 2019 to 2023 Infection and Drug Resistance severe acute pancreatitis pancreatic infection microbiological profiles multidrug-resistant organism risk factor |
| title | Characterization of Pancreatic Infections in Patients with Severe Acute Pancreatitis: A Retrospective Study from 2019 to 2023 |
| title_full | Characterization of Pancreatic Infections in Patients with Severe Acute Pancreatitis: A Retrospective Study from 2019 to 2023 |
| title_fullStr | Characterization of Pancreatic Infections in Patients with Severe Acute Pancreatitis: A Retrospective Study from 2019 to 2023 |
| title_full_unstemmed | Characterization of Pancreatic Infections in Patients with Severe Acute Pancreatitis: A Retrospective Study from 2019 to 2023 |
| title_short | Characterization of Pancreatic Infections in Patients with Severe Acute Pancreatitis: A Retrospective Study from 2019 to 2023 |
| title_sort | characterization of pancreatic infections in patients with severe acute pancreatitis a retrospective study from 2019 to 2023 |
| topic | severe acute pancreatitis pancreatic infection microbiological profiles multidrug-resistant organism risk factor |
| url | https://www.dovepress.com/characterization-of-pancreatic-infections-in-patients-with-severe-acut-peer-reviewed-fulltext-article-IDR |
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