An adenine model of inborn metabolism errors alters TDP-43 aggregation and reduces its toxicity in yeast revealing insights into protein misfolding diseases

An adenine model of inborn metabolism errors alters TDP-43 aggregation and reduces its toxicity in yeast revealing insights into protein misfolding diseases

TDP-43 is linked to human diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). Expression of TDP-43 in yeast is known to be toxic, cause cells to elongate, form liquid-like aggregates, and inhibit autophagy and TOROID formation. Here, we used the apt1∆ aah1∆ ye...

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Bibliographic Details
Main Authors: Sangeun Park, Sei-Kyoung Park, Peter Blair, Susan W. Liebman
Format: Article
Language:English
Published: Shared Science Publishers OG 2025-05-01
Series:Microbial Cell
Subjects:
yeast
tdp-43
liquid-like droplets
metabolite-based amyloids
frap
metabolism disorders
als
Online Access:http://microbialcell.com/researcharticles/2025a-park-microbial-cell
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