stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments
IntroductionTuberculosis (TB) poses a significant threat to global health, with millions of new infections and approximately one million deaths annually. Various modeling efforts have emerged, offering tailored data-driven and physiologically-based solutions for novel and historical compounds. Howev...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1462193/full |
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| author | Roberto Visintainer Anna Fochesato Anna Fochesato Daniele Boaretti Stefano Giampiccolo Stefano Giampiccolo Shayne Watson Micha Levi Federico Reali Luca Marchetti Luca Marchetti |
| author_facet | Roberto Visintainer Anna Fochesato Anna Fochesato Daniele Boaretti Stefano Giampiccolo Stefano Giampiccolo Shayne Watson Micha Levi Federico Reali Luca Marchetti Luca Marchetti |
| author_sort | Roberto Visintainer |
| collection | DOAJ |
| description | IntroductionTuberculosis (TB) poses a significant threat to global health, with millions of new infections and approximately one million deaths annually. Various modeling efforts have emerged, offering tailored data-driven and physiologically-based solutions for novel and historical compounds. However, this diverse modeling panorama may lack consistency, limiting result comparability. Drug-specific models are often tied to commercial software and developed on various platforms and languages, potentially hindering access and complicating the comparison of different compounds.MethodsThis work introduces stormTB: SimulaTOr of a muRine Minimal-pbpk model for anti-TB drugs. It is a web-based interface for our minimal physiologically based pharmacokinetic (mPBPK) platform, designed to simulate custom treatment scenarios for tuberculosis in murine models. The app facilitates visual comparisons of pharmacokinetic profiles, aiding in assessing drug-dose combinations.ResultsThe mPBPK model, supporting 11 anti-TB drugs, offers a unified perspective, overcoming the potential inconsistencies arising from diverse modeling efforts. The app, publicly accessible, provides a user-friendly environment for researchers to conduct what-if analyses and contribute to collective TB eradication efforts. The tool generates comprehensive visualizations of drug concentration profiles and pharmacokinetic/pharmacodynamic indices for TB-relevant tissues, empowering researchers in the quest for more effective TB treatments. stormTB is freely available at the link: https://apps.cosbi.eu/stormTB. |
| format | Article |
| id | doaj-art-e1c8a2f7de3842a684be1fc97dbd8ac9 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-e1c8a2f7de3842a684be1fc97dbd8ac92025-01-08T05:10:24ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.14621931462193stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatmentsRoberto Visintainer0Anna Fochesato1Anna Fochesato2Daniele Boaretti3Stefano Giampiccolo4Stefano Giampiccolo5Shayne Watson6Micha Levi7Federico Reali8Luca Marchetti9Luca Marchetti10Fondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, ItalyFondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, ItalyDepartment of Mathematics, University of Trento, Trento, ItalyFondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, ItalyFondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, ItalyDepartment of Information Engineering and Computer Science (DISI), University of Trento, Trento, ItalyGates Medical Research Institute, Cambridge, MA, United StatesGates Medical Research Institute, Cambridge, MA, United StatesFondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, ItalyFondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, ItalyDepartment of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, ItalyIntroductionTuberculosis (TB) poses a significant threat to global health, with millions of new infections and approximately one million deaths annually. Various modeling efforts have emerged, offering tailored data-driven and physiologically-based solutions for novel and historical compounds. However, this diverse modeling panorama may lack consistency, limiting result comparability. Drug-specific models are often tied to commercial software and developed on various platforms and languages, potentially hindering access and complicating the comparison of different compounds.MethodsThis work introduces stormTB: SimulaTOr of a muRine Minimal-pbpk model for anti-TB drugs. It is a web-based interface for our minimal physiologically based pharmacokinetic (mPBPK) platform, designed to simulate custom treatment scenarios for tuberculosis in murine models. The app facilitates visual comparisons of pharmacokinetic profiles, aiding in assessing drug-dose combinations.ResultsThe mPBPK model, supporting 11 anti-TB drugs, offers a unified perspective, overcoming the potential inconsistencies arising from diverse modeling efforts. The app, publicly accessible, provides a user-friendly environment for researchers to conduct what-if analyses and contribute to collective TB eradication efforts. The tool generates comprehensive visualizations of drug concentration profiles and pharmacokinetic/pharmacodynamic indices for TB-relevant tissues, empowering researchers in the quest for more effective TB treatments. stormTB is freely available at the link: https://apps.cosbi.eu/stormTB.https://www.frontiersin.org/articles/10.3389/fphar.2024.1462193/fullphysiologically based modelingpharmacokineticspharmacodynamicsADMEtuberculosisweb interface |
| spellingShingle | Roberto Visintainer Anna Fochesato Anna Fochesato Daniele Boaretti Stefano Giampiccolo Stefano Giampiccolo Shayne Watson Micha Levi Federico Reali Luca Marchetti Luca Marchetti stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments Frontiers in Pharmacology physiologically based modeling pharmacokinetics pharmacodynamics ADME tuberculosis web interface |
| title | stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments |
| title_full | stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments |
| title_fullStr | stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments |
| title_full_unstemmed | stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments |
| title_short | stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments |
| title_sort | stormtb a web based simulator of a murine minimal pbpk model for anti tuberculosis treatments |
| topic | physiologically based modeling pharmacokinetics pharmacodynamics ADME tuberculosis web interface |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1462193/full |
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