Protocol for effective surface passivation for single-molecule studies of chromatin and topoisomerase II

Protocol for effective surface passivation for single-molecule studies of chromatin and topoisomerase II

Summary: For single-molecule studies requiring surface anchoring of biomolecules, poorly passivated surfaces can result in alterations of biomolecule structure and function that lead to artifacts. Here, we present a surface passivation assay for single-molecule studies of chromatin and topoisomerase...

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Bibliographic Details
Main Authors: Tung T. Le, Xiang Gao, Seong Ha Park, Jaeyoon Lee, James T. Inman, Michelle D. Wang
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:STAR Protocols
Subjects:
biophysics
single-molecule assays
molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166724006658
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