Mitigating inflammation and fibrosis: the therapeutic potential of quercetin liposomes in COPD
IntroductionChronic obstructive pulmonary disease (COPD) is a disease with severe therapeutic obstacles and high worldwide death rate. COPD progresses predominantly through inflammatory response followed by fibrotic destruction. Quercetin (Que), recognized for its anti-inflammatory effects, presents...
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Frontiers Media S.A.
2024-12-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1503283/full |
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| author | Changfeng Yin Changfeng Yin Changfeng Yin Yushan Tian Yushan Tian Yushan Tian An Yan Hongjuan Wang Hongjuan Wang Hongjuan Wang Fengjun Lu Fengjun Lu Xianmei Li Xianmei Li Xiao Li Xiao Li Xiao Li Shulei Han Shulei Han Shulei Han Ruijuan Miao Ruijuan Miao Huan Chen Huan Chen Huan Chen Di Li Hongwei Hou Hongwei Hou Hongwei Hou Qingyuan Hu Qingyuan Hu Qingyuan Hu |
| author_facet | Changfeng Yin Changfeng Yin Changfeng Yin Yushan Tian Yushan Tian Yushan Tian An Yan Hongjuan Wang Hongjuan Wang Hongjuan Wang Fengjun Lu Fengjun Lu Xianmei Li Xianmei Li Xiao Li Xiao Li Xiao Li Shulei Han Shulei Han Shulei Han Ruijuan Miao Ruijuan Miao Huan Chen Huan Chen Huan Chen Di Li Hongwei Hou Hongwei Hou Hongwei Hou Qingyuan Hu Qingyuan Hu Qingyuan Hu |
| author_sort | Changfeng Yin |
| collection | DOAJ |
| description | IntroductionChronic obstructive pulmonary disease (COPD) is a disease with severe therapeutic obstacles and high worldwide death rate. COPD progresses predominantly through inflammatory response followed by fibrotic destruction. Quercetin (Que), recognized for its anti-inflammatory effects, presents significant promise as a therapeutic candidate for COPD therapy. However, poor water solubility and low bioavailability of Que hinder its further clinical application. Liposomes are renowned for their unique structure and function, which provided an efficient approach for the delivery of Que in various drug delivery systems. This study was aim to prepare a novel Que liposome (Que-lipo) and administrated via intratracheal (i.t.) with cigarette smoke induced COPD mice. The underlying therapeutic mechanisms against lung damage of Que-lipo were explored.MethodsQue-lipo were prepared based on thin film dispersion method and administrated via intratracheal administration. The cigarette smoke induced COPD mice were established and a comprehensive approach was employed to explore the inflammation, pulmonary function and histopathology of lung after i.t. administration of Que-lipo, including enzyme-linked immunosorbent assay, histopathology and immunohistochemistry, reverse transcription-quantitative polymerase chain reaction.Results and discussionQue-lipo not only improved the solubility and biocompatibility of Que but also demonstrated effective cellular uptake in vitro. The inflammation, pulmonary function and pathological condition of lung were improved after i.t. administration of Que-lipo. Que-lipo also regulated the expression of key apoptosis-associated proteins such as Bcl-2 and caspase-3/7, leading to significant inhibition of apoptotic activity in COPD. Furthermore, Que-lipo markedly enhanced its ability to alleviate lung inflammation and fibrosis symptoms by modulating inflammation-related factors and fibrosis signaling molecules. The potential mechanisms of Que-lipo in treating COPD were elucidated, including the suppression of the NLRP3/IL-1β inflammasome pathway and the TGF-β1-related fibrosis signaling pathway. |
| format | Article |
| id | doaj-art-e10e5e94ac8b4ce2bfff92dc2cc7f76c |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-e10e5e94ac8b4ce2bfff92dc2cc7f76c2024-12-17T06:23:09ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-12-011510.3389/fphar.2024.15032831503283Mitigating inflammation and fibrosis: the therapeutic potential of quercetin liposomes in COPDChangfeng Yin0Changfeng Yin1Changfeng Yin2Yushan Tian3Yushan Tian4Yushan Tian5An Yan6Hongjuan Wang7Hongjuan Wang8Hongjuan Wang9Fengjun Lu10Fengjun Lu11Xianmei Li12Xianmei Li13Xiao Li14Xiao Li15Xiao Li16Shulei Han17Shulei Han18Shulei Han19Ruijuan Miao20Ruijuan Miao21Huan Chen22Huan Chen23Huan Chen24Di Li25Hongwei Hou26Hongwei Hou27Hongwei Hou28Qingyuan Hu29Qingyuan Hu30Qingyuan Hu31China National Tobacco Quality Supervision & Test Center, Zhengzhou, ChinaBeijing Life Science Academy, Beijing, ChinaKey Laboratory of Tobacco Biological Effects, Zhengzhou, ChinaChina National Tobacco Quality Supervision & Test Center, Zhengzhou, ChinaBeijing Life Science Academy, Beijing, ChinaKey Laboratory of Tobacco Biological Effects, Zhengzhou, ChinaSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai, ChinaChina National Tobacco Quality Supervision & Test Center, Zhengzhou, ChinaBeijing Life Science Academy, Beijing, ChinaKey Laboratory of Tobacco Biological Effects, Zhengzhou, ChinaChina National Tobacco Quality Supervision & Test Center, Zhengzhou, ChinaKey Laboratory of Tobacco Biological Effects, Zhengzhou, ChinaChina National Tobacco Quality Supervision & Test Center, Zhengzhou, ChinaKey Laboratory of Tobacco Biological Effects, Zhengzhou, ChinaChina National Tobacco Quality Supervision & Test Center, Zhengzhou, ChinaBeijing Life Science Academy, Beijing, ChinaKey Laboratory of Tobacco Biological Effects, Zhengzhou, ChinaChina National Tobacco Quality Supervision & Test Center, Zhengzhou, ChinaBeijing Life Science Academy, Beijing, ChinaKey Laboratory of Tobacco Biological Effects, Zhengzhou, ChinaChina National Tobacco Quality Supervision & Test Center, Zhengzhou, ChinaKey Laboratory of Tobacco Biological Effects, Zhengzhou, ChinaChina National Tobacco Quality Supervision & Test Center, Zhengzhou, ChinaBeijing Life Science Academy, Beijing, ChinaKey Laboratory of Tobacco Biological Effects, Zhengzhou, ChinaSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai, ChinaChina National Tobacco Quality Supervision & Test Center, Zhengzhou, ChinaBeijing Life Science Academy, Beijing, ChinaKey Laboratory of Tobacco Biological Effects, Zhengzhou, ChinaChina National Tobacco Quality Supervision & Test Center, Zhengzhou, ChinaBeijing Life Science Academy, Beijing, ChinaKey Laboratory of Tobacco Biological Effects, Zhengzhou, ChinaIntroductionChronic obstructive pulmonary disease (COPD) is a disease with severe therapeutic obstacles and high worldwide death rate. COPD progresses predominantly through inflammatory response followed by fibrotic destruction. Quercetin (Que), recognized for its anti-inflammatory effects, presents significant promise as a therapeutic candidate for COPD therapy. However, poor water solubility and low bioavailability of Que hinder its further clinical application. Liposomes are renowned for their unique structure and function, which provided an efficient approach for the delivery of Que in various drug delivery systems. This study was aim to prepare a novel Que liposome (Que-lipo) and administrated via intratracheal (i.t.) with cigarette smoke induced COPD mice. The underlying therapeutic mechanisms against lung damage of Que-lipo were explored.MethodsQue-lipo were prepared based on thin film dispersion method and administrated via intratracheal administration. The cigarette smoke induced COPD mice were established and a comprehensive approach was employed to explore the inflammation, pulmonary function and histopathology of lung after i.t. administration of Que-lipo, including enzyme-linked immunosorbent assay, histopathology and immunohistochemistry, reverse transcription-quantitative polymerase chain reaction.Results and discussionQue-lipo not only improved the solubility and biocompatibility of Que but also demonstrated effective cellular uptake in vitro. The inflammation, pulmonary function and pathological condition of lung were improved after i.t. administration of Que-lipo. Que-lipo also regulated the expression of key apoptosis-associated proteins such as Bcl-2 and caspase-3/7, leading to significant inhibition of apoptotic activity in COPD. Furthermore, Que-lipo markedly enhanced its ability to alleviate lung inflammation and fibrosis symptoms by modulating inflammation-related factors and fibrosis signaling molecules. The potential mechanisms of Que-lipo in treating COPD were elucidated, including the suppression of the NLRP3/IL-1β inflammasome pathway and the TGF-β1-related fibrosis signaling pathway.https://www.frontiersin.org/articles/10.3389/fphar.2024.1503283/fullchronic obstructive pulmonary diseaseinflammationfibrosisquercetinliposomes |
| spellingShingle | Changfeng Yin Changfeng Yin Changfeng Yin Yushan Tian Yushan Tian Yushan Tian An Yan Hongjuan Wang Hongjuan Wang Hongjuan Wang Fengjun Lu Fengjun Lu Xianmei Li Xianmei Li Xiao Li Xiao Li Xiao Li Shulei Han Shulei Han Shulei Han Ruijuan Miao Ruijuan Miao Huan Chen Huan Chen Huan Chen Di Li Hongwei Hou Hongwei Hou Hongwei Hou Qingyuan Hu Qingyuan Hu Qingyuan Hu Mitigating inflammation and fibrosis: the therapeutic potential of quercetin liposomes in COPD Frontiers in Pharmacology chronic obstructive pulmonary disease inflammation fibrosis quercetin liposomes |
| title | Mitigating inflammation and fibrosis: the therapeutic potential of quercetin liposomes in COPD |
| title_full | Mitigating inflammation and fibrosis: the therapeutic potential of quercetin liposomes in COPD |
| title_fullStr | Mitigating inflammation and fibrosis: the therapeutic potential of quercetin liposomes in COPD |
| title_full_unstemmed | Mitigating inflammation and fibrosis: the therapeutic potential of quercetin liposomes in COPD |
| title_short | Mitigating inflammation and fibrosis: the therapeutic potential of quercetin liposomes in COPD |
| title_sort | mitigating inflammation and fibrosis the therapeutic potential of quercetin liposomes in copd |
| topic | chronic obstructive pulmonary disease inflammation fibrosis quercetin liposomes |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1503283/full |
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