Investigating hepatic fibrosis heterogeneity by three-dimensional imaging in metabolic dysfunction-associated steatotic liver disease

Investigating hepatic fibrosis heterogeneity by three-dimensional imaging in metabolic dysfunction-associated steatotic liver disease

Abstract Although liver biopsy is a well-established technique to assess fibrosis it has several limitations, including invasive nature, semi-quantitative assessment methods, significant sampling and observer variability, making precise assessment of hepatic fibrosis challenging. Accurate and reliab...

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Main Authors: Buket Yigit, Ekin Ozgonul, Omer Yaman, Tarik Sipahioglu, Burge Ulukan, Yagmur Cetin Tas, Berna Morova, Musa Aydin, Yigit Uysalli, Elif Demirtas, Mert Erkan, Gurkan Tellioglu, Dila Atak, Yasemin Gursoy Ozdemir, Sercin Karahuseyinoglu, Cihan Yurdaydin, Murat Akyildiz, Abhishek Sheth, Guruprasad Padur Aithal, Hale Kirimlioglu, Murat Dayangac, Onur Ferhanoglu, Alper Kiraz, Müjdat Zeybel
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Liver fibrosis
Slide-free pathology
CLARITY
3D imaging
MASLD
Online Access:https://doi.org/10.1038/s41598-025-98680-y
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https://doi.org/10.1038/s41598-025-98680-y

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