PTPN23-dependent ESCRT machinery functions as a cell death checkpoint

PTPN23-dependent ESCRT machinery functions as a cell death checkpoint

Abstract Cell death plasticity is crucial for modulating tissue homeostasis and immune responses, but our understanding of the molecular components that regulate cell death pathways to determine cell fate remains limited. Here, a CRISPR screen of acute myeloid leukemia cells identifies protein tyros...

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Main Authors: Dongyan Song, Yuxin Cen, Zhe Qian, Xiaoli S. Wu, Keith Rivera, Tse-Luen Wee, Osama E. Demerdash, Kenneth Chang, Darryl Pappin, Christopher R. Vakoc, Nicholas K. Tonks
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54749-2
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https://doi.org/10.1038/s41467-024-54749-2

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