The deregulated physiology in oral squamous cell carcinoma- a brief review
Cancer is a major health burden globally. Not only the disease but also its treatment ravages a patient afflicted with it. Decoding its pathogenesis in entirety and the process through which it is able to not only survive but also grow indefinitely despite the inherent immune mechanisms of the human...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024001705 |
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| author | Keerthika Saravanan Madhu Narayan Krishnan Rajkumar |
| author_facet | Keerthika Saravanan Madhu Narayan Krishnan Rajkumar |
| author_sort | Keerthika Saravanan |
| collection | DOAJ |
| description | Cancer is a major health burden globally. Not only the disease but also its treatment ravages a patient afflicted with it. Decoding its pathogenesis in entirety and the process through which it is able to not only survive but also grow indefinitely despite the inherent immune mechanisms of the human body is an area of continuous research. In cancer biology, hallmarks of cancer represent the normal physiology gone astray such as sustaining proliferative signaling, evading growth suppressors, avoiding immune destruction, activating invasion and metastasis, tumor promoting inflammation, enabling replicative immortality, inducing angiogenesis and resisting cell death that thus serve as blueprints for understanding core cancer characteristics. The main aim of this review is to get a general understanding of the mechanisms in which the physiology gets deregulated in oral squamous cell carcinoma and to highlight its importance in producing an effective treatment through targeting them. To write this review article, databases like PubMed, Embase, Cochrane and Google Scholar were searched and those articles relating to the hallmarks of cancer published in English between 1993 and 2023 were considered. The applicable data was extracted from the related articles and included in a single review. |
| format | Article |
| id | doaj-art-e095124850d64740a657a936501585d7 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-e095124850d64740a657a936501585d72025-01-09T06:15:49ZengElsevierOral Oncology Reports2772-90602024-06-0110100324The deregulated physiology in oral squamous cell carcinoma- a brief reviewKeerthika Saravanan0Madhu Narayan1Krishnan Rajkumar2Dept. of Oral Pathology, SRM Dental college, Ramapuram, Chennai, 600089, IndiaCorresponding author.; Dept. of Oral Pathology, SRM Dental college, Ramapuram, Chennai, 600089, IndiaDept. of Oral Pathology, SRM Dental college, Ramapuram, Chennai, 600089, IndiaCancer is a major health burden globally. Not only the disease but also its treatment ravages a patient afflicted with it. Decoding its pathogenesis in entirety and the process through which it is able to not only survive but also grow indefinitely despite the inherent immune mechanisms of the human body is an area of continuous research. In cancer biology, hallmarks of cancer represent the normal physiology gone astray such as sustaining proliferative signaling, evading growth suppressors, avoiding immune destruction, activating invasion and metastasis, tumor promoting inflammation, enabling replicative immortality, inducing angiogenesis and resisting cell death that thus serve as blueprints for understanding core cancer characteristics. The main aim of this review is to get a general understanding of the mechanisms in which the physiology gets deregulated in oral squamous cell carcinoma and to highlight its importance in producing an effective treatment through targeting them. To write this review article, databases like PubMed, Embase, Cochrane and Google Scholar were searched and those articles relating to the hallmarks of cancer published in English between 1993 and 2023 were considered. The applicable data was extracted from the related articles and included in a single review.http://www.sciencedirect.com/science/article/pii/S2772906024001705CancerOral squamous cell carcinomaDeregulatedPhysiologyHallmarks |
| spellingShingle | Keerthika Saravanan Madhu Narayan Krishnan Rajkumar The deregulated physiology in oral squamous cell carcinoma- a brief review Oral Oncology Reports Cancer Oral squamous cell carcinoma Deregulated Physiology Hallmarks |
| title | The deregulated physiology in oral squamous cell carcinoma- a brief review |
| title_full | The deregulated physiology in oral squamous cell carcinoma- a brief review |
| title_fullStr | The deregulated physiology in oral squamous cell carcinoma- a brief review |
| title_full_unstemmed | The deregulated physiology in oral squamous cell carcinoma- a brief review |
| title_short | The deregulated physiology in oral squamous cell carcinoma- a brief review |
| title_sort | deregulated physiology in oral squamous cell carcinoma a brief review |
| topic | Cancer Oral squamous cell carcinoma Deregulated Physiology Hallmarks |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024001705 |
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