Homeostatic pockets of interferon lambda-stimulated gene production in the intestine are associated with localized exposure to bacterial microbiota

Homeostatic pockets of interferon lambda-stimulated gene production in the intestine are associated with localized exposure to bacterial microbiota

Tolerance of enteric microbiota and clearance of potential pathogens is critical for gut homeostasis. We previously found that the healthy small intestine of mice contains discrete pockets of antiviral gene expression that depend on bacterial microbiota colonization and interferon lambda (IFN-λ) rec...

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Bibliographic Details
Main Authors: David A. Constant, Jacob A. Van Winkle, Kimberly A. Meyer, Shelby R. Madden, Bryan Ramirez Reyes, Timothy J. Nice
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Interferon lambda
innate immunity
intestinal epithelium
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2024.2447830
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https://www.tandfonline.com/doi/10.1080/19490976.2024.2447830

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