Histological hallmarks and role of Slug/PIP axis in pulmonary hypertension secondary to pulmonary fibrosis

Histological hallmarks and role of Slug/PIP axis in pulmonary hypertension secondary to pulmonary fibrosis

Abstract Pulmonary hypertension secondary to pulmonary fibrosis (PF‐PH) is one of the most common causes of PH, and there is no approved therapy. The molecular signature of PF‐PH and underlying mechanism of why pulmonary hypertension (PH) develops in PF patients remains understudied and poorly under...

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Main Authors: Gregoire Ruffenach, Soban Umar, Mylene Vaillancourt, Jason Hong, Nancy Cao, Shervin Sarji, Shayan Moazeni, Christine M Cunningham, Abbas Ardehali, Srinivasa T Reddy, Rajan Saggar, Gregory Fishbein, Mansoureh Eghbali
Format: Article
Language:English
Published: Springer Nature 2019-08-01
Series:EMBO Molecular Medicine
Subjects:
non‐fibrotic area
prolactin‐induced protein
Slug
vascular remodeling
Online Access:https://doi.org/10.15252/emmm.201810061
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https://doi.org/10.15252/emmm.201810061

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