Dose-Dependent Cognitive Decline, Anxiety, and Locomotor Impairments Induced by Doxorubicin: Evidence from an Animal Model

Dose-Dependent Cognitive Decline, Anxiety, and Locomotor Impairments Induced by Doxorubicin: Evidence from an Animal Model

Cognitive impairment and anxiety are common side effects of chemotherapy, particularly with the use of doxorubicin (DOX), known as “chemobrain”. This study aimed to examine the dose-dependent effects of DOX on cognitive decline, anxiety, and locomotor activity in healthy female Wistar rats. The rats...

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Bibliographic Details
Main Authors: Ângela Amaro-Leal, Ana I. Afonso, Filipa Machado, Liana Shvachiy, Isabel Rocha, Tiago F. Outeiro, Vera Geraldes
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biology
Subjects:
doxorubicin
anxiety
chemotherapy-induced cognitive impairment
cognitive dysfunction
Online Access:https://www.mdpi.com/2079-7737/13/11/939
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