Prediction of vancomycin plasma concentration in elderly patients based on multi-algorithm mining combined with population pharmacokinetics

Prediction of vancomycin plasma concentration in elderly patients based on multi-algorithm mining combined with population pharmacokinetics

Abstract The pharmacokinetics of vancomycin exhibit significant inter-individual variability, particularly among elderly patients. This study aims to develop a predictive model that integrates machine learning with population pharmacokinetics (popPK) to facilitate personalized medication management...

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Bibliographic Details
Main Authors: Pan Ma, Huan Ma, Ruixiang Liu, Haini Wen, Haisheng Li, Yifan Huang, Ying Li, Lirong Xiong, Linli Xie, Qian Wang
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Vancomycin
Elderly
Machine learning
Population pharmacokinetics
Feature selection
Precision medicine
Online Access:https://doi.org/10.1038/s41598-024-78558-1
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https://doi.org/10.1038/s41598-024-78558-1

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