Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases Sestrin2 expression and reduces methylglyoxal toxicity

Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases Sestrin2 expression and reduces methylglyoxal toxicity

Unfolded protein response (UPR) is activated in cells under endoplasmic reticulum (ER) stress. One sensor protein involved in this response is PERK, which is activated through its redox-dependent oligomerization. Prolonged UPR activation is associated with the development and progression of various...

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Bibliographic Details
Main Authors: Shin Koike, Hideo Kimura, Yuki Ogasawara
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Redox Biology
Subjects:
UPR pathway
Polysulfide
Persulfide
Sestrin2
Methylglyoxal
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724004282
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