Revisiting the molecular landscape of Rosai-Dorfman disease: insights from whole exome sequencing of Saudi patients

Revisiting the molecular landscape of Rosai-Dorfman disease: insights from whole exome sequencing of Saudi patients

Rosai-Dorfman disease (RDD) has traditionally been viewed as a reactive histiocytic disorder, defined by its unique clinical features and immunophenotype. However, recent genetic studies suggest a more complex molecular landscape, challenging the notion of RDD as solely reactive and hinting at a pos...

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Bibliographic Details
Main Authors: Sarah Binhassan, Manar Samman, Yazeed Al-Sheikh, Wafaa Alshakweer, Tahani Alhalouli, Najd Alshamlan, Manal Abudawood
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
Rosai-Dorfman disease
whole exome sequencing
molecular markers
BRCA1 mutation
genetic landscape
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1556830/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1556830/full

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