Association of uveitis with pediatric autoimmune diseases based on a TriNetX study
Abstract To investigate for the risk of uveitis among such patients. A retrospective cohort study utilized the TriNetX database and recruited pediatric autoimmune patients diagnosed between January 1st 2004 and December 31st 2022. The non-autoimmune cohort were randomly selected control patients mat...
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-79262-w |
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| author | Alan Y. Hsu Hou-Ting Kuo Chun-Ju Lin Chang-Ching Wei Ning-Yi Hsia James Cheng-Chung Wei Yu-Hsun Wang You-Ling Li Chun-Ting Lai Huan-Sheng Chen Yi-Yu Tsai |
| author_facet | Alan Y. Hsu Hou-Ting Kuo Chun-Ju Lin Chang-Ching Wei Ning-Yi Hsia James Cheng-Chung Wei Yu-Hsun Wang You-Ling Li Chun-Ting Lai Huan-Sheng Chen Yi-Yu Tsai |
| author_sort | Alan Y. Hsu |
| collection | DOAJ |
| description | Abstract To investigate for the risk of uveitis among such patients. A retrospective cohort study utilized the TriNetX database and recruited pediatric autoimmune patients diagnosed between January 1st 2004 and December 31st 2022. The non-autoimmune cohort were randomly selected control patients matched by sex, age, and index year. The main outcome is the incidence of new-onset uveitis. 175,328 pediatric patients with autoimmune diseases (mean age 10.7 +/- 5.1 years; 55.8% female; 66.2% White) and 175,328 pediatric patients without autoimmune diseases (mean age 10.8+/- 5.1 years; 55.7% female; 66% White) were recruited. The autoimmune cohort demonstrated a significantly increased uveitis risk across our 18-year study period (HR 4.42 [95% CI 3.98–4.90]). Iridocyclitis, chorioretinal inflammation, unspecified purulent endophthalmitis, panuveitis, retinal vasculitis, and sympathetic uveitis were uveitis conditions significantly associated with autoimmune diseases. Autoimmune patients who had used immunosuppressant medications had increased uveitis risk compared to those who had never used immunosuppressants. Our subgroup analysis also demonstrated a significantly increased uveitis risk associated with specific autoimmune conditions. Conditions include inflammatory arthritis, systemic autoimmune rheumatic diseases, systemic vasculitis, inflammatory bowel disease, psoriasis, multiple sclerosis, and immune thrombocytopenic purpura. Using hazard ratios HR for comparison, we were able to identify that, out of the previously broadly defined category of autoimmune diseases, only these specific conditions were significantly associated with pediatric uveitis. Uveitis was significantly associated with autoimmune diseases among the pediatric population. |
| format | Article |
| id | doaj-art-dfe0bb8873564343aaf4c7ef84294d94 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-dfe0bb8873564343aaf4c7ef84294d942025-01-05T12:28:35ZengNature PortfolioScientific Reports2045-23222024-12-0114111010.1038/s41598-024-79262-wAssociation of uveitis with pediatric autoimmune diseases based on a TriNetX studyAlan Y. Hsu0Hou-Ting Kuo1Chun-Ju Lin2Chang-Ching Wei3Ning-Yi Hsia4James Cheng-Chung Wei5Yu-Hsun Wang6You-Ling Li7Chun-Ting Lai8Huan-Sheng Chen9Yi-Yu Tsai10Department of Ophthalmology, China Medical University Hospital, China Medical UniversityDepartment of Ophthalmology, China Medical University Hospital, China Medical UniversityDepartment of Ophthalmology, China Medical University Hospital, China Medical UniversitySchool of Medicine, College of Medicine, China Medical UniversityDepartment of Ophthalmology, China Medical University Hospital, China Medical UniversityDepartment of Medical Research, Chung Shan Medical University HospitalDepartment of Medical Research, Chung Shan Medical University HospitalDepartment of Ophthalmology, China Medical University Hospital, China Medical UniversityDepartment of Ophthalmology, China Medical University Hospital, China Medical UniversityAn-Shin Dialysis Center, Excelsior Renal Service Co., Ltd. Taiwan BranchDepartment of Ophthalmology, China Medical University Hospital, China Medical UniversityAbstract To investigate for the risk of uveitis among such patients. A retrospective cohort study utilized the TriNetX database and recruited pediatric autoimmune patients diagnosed between January 1st 2004 and December 31st 2022. The non-autoimmune cohort were randomly selected control patients matched by sex, age, and index year. The main outcome is the incidence of new-onset uveitis. 175,328 pediatric patients with autoimmune diseases (mean age 10.7 +/- 5.1 years; 55.8% female; 66.2% White) and 175,328 pediatric patients without autoimmune diseases (mean age 10.8+/- 5.1 years; 55.7% female; 66% White) were recruited. The autoimmune cohort demonstrated a significantly increased uveitis risk across our 18-year study period (HR 4.42 [95% CI 3.98–4.90]). Iridocyclitis, chorioretinal inflammation, unspecified purulent endophthalmitis, panuveitis, retinal vasculitis, and sympathetic uveitis were uveitis conditions significantly associated with autoimmune diseases. Autoimmune patients who had used immunosuppressant medications had increased uveitis risk compared to those who had never used immunosuppressants. Our subgroup analysis also demonstrated a significantly increased uveitis risk associated with specific autoimmune conditions. Conditions include inflammatory arthritis, systemic autoimmune rheumatic diseases, systemic vasculitis, inflammatory bowel disease, psoriasis, multiple sclerosis, and immune thrombocytopenic purpura. Using hazard ratios HR for comparison, we were able to identify that, out of the previously broadly defined category of autoimmune diseases, only these specific conditions were significantly associated with pediatric uveitis. Uveitis was significantly associated with autoimmune diseases among the pediatric population.https://doi.org/10.1038/s41598-024-79262-wAutoimmuneTriNetXUveitisOphthalmologyPediatrics |
| spellingShingle | Alan Y. Hsu Hou-Ting Kuo Chun-Ju Lin Chang-Ching Wei Ning-Yi Hsia James Cheng-Chung Wei Yu-Hsun Wang You-Ling Li Chun-Ting Lai Huan-Sheng Chen Yi-Yu Tsai Association of uveitis with pediatric autoimmune diseases based on a TriNetX study Scientific Reports Autoimmune TriNetX Uveitis Ophthalmology Pediatrics |
| title | Association of uveitis with pediatric autoimmune diseases based on a TriNetX study |
| title_full | Association of uveitis with pediatric autoimmune diseases based on a TriNetX study |
| title_fullStr | Association of uveitis with pediatric autoimmune diseases based on a TriNetX study |
| title_full_unstemmed | Association of uveitis with pediatric autoimmune diseases based on a TriNetX study |
| title_short | Association of uveitis with pediatric autoimmune diseases based on a TriNetX study |
| title_sort | association of uveitis with pediatric autoimmune diseases based on a trinetx study |
| topic | Autoimmune TriNetX Uveitis Ophthalmology Pediatrics |
| url | https://doi.org/10.1038/s41598-024-79262-w |
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