Adverse Cardiovascular Effects of Nicotine Delivered by Chronic Electronic Cigarettes or Standard Cigarettes Captured by Cardiovascular Intrinsic Frequencies
Background Electronic cigarettes have gained popularity as a nicotine delivery system, which has been recommended by some as an aid to help people quit traditional smoking. The potential long‐term effects of vaping on the cardiovascular system, as well as how their effects compare with those from st...
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| Format: | Article |
| Language: | English |
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Wiley
2024-09-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.124.035462 |
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| author | Rashid Alavi Wangde Dai Sohrab P. Mazandarani Rebecca J. Arechavala David A. Herman Michael T. Kleinman Robert A. Kloner Niema M. Pahlevan |
| author_facet | Rashid Alavi Wangde Dai Sohrab P. Mazandarani Rebecca J. Arechavala David A. Herman Michael T. Kleinman Robert A. Kloner Niema M. Pahlevan |
| author_sort | Rashid Alavi |
| collection | DOAJ |
| description | Background Electronic cigarettes have gained popularity as a nicotine delivery system, which has been recommended by some as an aid to help people quit traditional smoking. The potential long‐term effects of vaping on the cardiovascular system, as well as how their effects compare with those from standard cigarettes, are not well understood. The intrinsic frequency (IF) method is a systems approach for analysis of left ventricle and arterial function. Recent clinical studies have demonstrated the diagnostic and prognostic value of IF. Here, we aim to determine whether the novel IF metrics derived from carotid pressure waveforms can detect effects of nicotine (delivered by chronic exposure to electronic cigarette vapor or traditional cigarette smoke) on the cardiovascular system. Methods and Results One hundred seventeen healthy adult male and female rats were exposed to purified air (control), electronic cigarette vapor without nicotine, electronic cigarette vapor with nicotine, and traditional nicotine‐rich cigarette smoke, after which hemodynamics were comprehensively evaluated. IF metrics were computed from invasive carotid pressure waveforms. Standard cigarettes significantly increased the first IF (indicating left ventricle contractile dysfunction). Electronic cigarettes with nicotine significantly reduced the second IF (indicating adverse effects on vascular function). No significant difference was seen in the IF metrics between controls and electronic cigarettes without nicotine. Exposure to electronic cigarettes with nicotine significantly increased the total IF variation (suggesting adverse effects on left ventricle‐arterial coupling and its optimal state), when compared with electronic cigarettes without nicotine. Conclusions Our IF results suggest that nicotine‐containing electronic cigarettes adversely affect vascular function and left ventricle‐arterial coupling, whereas standard cigarettes have an adverse effect on left ventricle function. |
| format | Article |
| id | doaj-art-dfc27599a5c34e339e36992e9bb38f08 |
| institution | Kabale University |
| issn | 2047-9980 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-dfc27599a5c34e339e36992e9bb38f082024-11-28T12:39:09ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802024-09-01131810.1161/JAHA.124.035462Adverse Cardiovascular Effects of Nicotine Delivered by Chronic Electronic Cigarettes or Standard Cigarettes Captured by Cardiovascular Intrinsic FrequenciesRashid Alavi0Wangde Dai1Sohrab P. Mazandarani2Rebecca J. Arechavala3David A. Herman4Michael T. Kleinman5Robert A. Kloner6Niema M. Pahlevan7Department of Aerospace and Mechanical Engineering University of Southern California Los Angeles CADivision of Cardiovascular Medicine, Keck School of Medicine University of Southern California Los Angeles CADivision of Cardiovascular Medicine, Keck School of Medicine University of Southern California Los Angeles CADepartment of Environmental and Occupational Health, College of Health Sciences University of California Irvine CADepartment of Environmental and Occupational Health, College of Health Sciences University of California Irvine CADepartment of Environmental and Occupational Health, College of Health Sciences University of California Irvine CADivision of Cardiovascular Medicine, Keck School of Medicine University of Southern California Los Angeles CADepartment of Aerospace and Mechanical Engineering University of Southern California Los Angeles CABackground Electronic cigarettes have gained popularity as a nicotine delivery system, which has been recommended by some as an aid to help people quit traditional smoking. The potential long‐term effects of vaping on the cardiovascular system, as well as how their effects compare with those from standard cigarettes, are not well understood. The intrinsic frequency (IF) method is a systems approach for analysis of left ventricle and arterial function. Recent clinical studies have demonstrated the diagnostic and prognostic value of IF. Here, we aim to determine whether the novel IF metrics derived from carotid pressure waveforms can detect effects of nicotine (delivered by chronic exposure to electronic cigarette vapor or traditional cigarette smoke) on the cardiovascular system. Methods and Results One hundred seventeen healthy adult male and female rats were exposed to purified air (control), electronic cigarette vapor without nicotine, electronic cigarette vapor with nicotine, and traditional nicotine‐rich cigarette smoke, after which hemodynamics were comprehensively evaluated. IF metrics were computed from invasive carotid pressure waveforms. Standard cigarettes significantly increased the first IF (indicating left ventricle contractile dysfunction). Electronic cigarettes with nicotine significantly reduced the second IF (indicating adverse effects on vascular function). No significant difference was seen in the IF metrics between controls and electronic cigarettes without nicotine. Exposure to electronic cigarettes with nicotine significantly increased the total IF variation (suggesting adverse effects on left ventricle‐arterial coupling and its optimal state), when compared with electronic cigarettes without nicotine. Conclusions Our IF results suggest that nicotine‐containing electronic cigarettes adversely affect vascular function and left ventricle‐arterial coupling, whereas standard cigarettes have an adverse effect on left ventricle function.https://www.ahajournals.org/doi/10.1161/JAHA.124.035462arterial pressure waveformcardiovascular intrinsic frequencycombustion cigarette smokingelectronic cigarettenicotine |
| spellingShingle | Rashid Alavi Wangde Dai Sohrab P. Mazandarani Rebecca J. Arechavala David A. Herman Michael T. Kleinman Robert A. Kloner Niema M. Pahlevan Adverse Cardiovascular Effects of Nicotine Delivered by Chronic Electronic Cigarettes or Standard Cigarettes Captured by Cardiovascular Intrinsic Frequencies Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease arterial pressure waveform cardiovascular intrinsic frequency combustion cigarette smoking electronic cigarette nicotine |
| title | Adverse Cardiovascular Effects of Nicotine Delivered by Chronic Electronic Cigarettes or Standard Cigarettes Captured by Cardiovascular Intrinsic Frequencies |
| title_full | Adverse Cardiovascular Effects of Nicotine Delivered by Chronic Electronic Cigarettes or Standard Cigarettes Captured by Cardiovascular Intrinsic Frequencies |
| title_fullStr | Adverse Cardiovascular Effects of Nicotine Delivered by Chronic Electronic Cigarettes or Standard Cigarettes Captured by Cardiovascular Intrinsic Frequencies |
| title_full_unstemmed | Adverse Cardiovascular Effects of Nicotine Delivered by Chronic Electronic Cigarettes or Standard Cigarettes Captured by Cardiovascular Intrinsic Frequencies |
| title_short | Adverse Cardiovascular Effects of Nicotine Delivered by Chronic Electronic Cigarettes or Standard Cigarettes Captured by Cardiovascular Intrinsic Frequencies |
| title_sort | adverse cardiovascular effects of nicotine delivered by chronic electronic cigarettes or standard cigarettes captured by cardiovascular intrinsic frequencies |
| topic | arterial pressure waveform cardiovascular intrinsic frequency combustion cigarette smoking electronic cigarette nicotine |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.124.035462 |
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