Differences in age-related distribution of CSF alpha-synuclein seeding and Alzheimer profiles between PD with and without GBA1 variants

Differences in age-related distribution of CSF alpha-synuclein seeding and Alzheimer profiles between PD with and without GBA1 variants

Abstract We studied the age- and genetic-related prevalence of CSF alpha-Synuclein seeding and Alzheimer profiles in 188 samples from PD participants without GBA1 variants (PDwildtype) and in 129 samples from PD participants with GBA1 variants (PDGBA1). While Alzheimer profiles increased with age in...

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Main Authors: Stefanie Lerche, Isabel Wurster, Benjamin Roeben, Milan Zimmermann, Marcello Rossi, Angela Mammana, Simone Baiardi, Ann‑Kathrin Hauser, Christian Deuschle, Claudia Schulte, Piero Parchi, Kathrin Brockmann
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-00978-1
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https://doi.org/10.1038/s41531-025-00978-1

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