Early in vitro results indicate that de-O-acetylated sialic acids increase Selectin binding in cancers

Early in vitro results indicate that de-O-acetylated sialic acids increase Selectin binding in cancers

Cancers utilize a simple glycan, Sialic Acid, to engage in metastatic processes via the Sialic acid (Sia) -Selectin pathway. Selectins recognize and bind to sialylated substrates, resulting in adhesion, migration, and extravasation, however, how deviations from the canonical form of Sia regulate...

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Bibliographic Details
Main Authors: Kakali Das, Megan Schulte, Megan Gerhart, Hala Bayoumi, Delayna Paulson, Darci M. Fink, Colin Parrish, Rachel Willand-Charnley
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Oncology
Subjects:
de-O-acetylated sialic acid
cancer
selectins
sia-selectin pathway
Sialyl Lewis X
PSGL-1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1443303/full
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https://www.frontiersin.org/articles/10.3389/fonc.2024.1443303/full

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