Immune profiling identifies CD161+CD127+CD8+ T cells as a predictive biomarker for Anti-PD-L1 therapy response in the SCLC-I subtype

Immune profiling identifies CD161+CD127+CD8+ T cells as a predictive biomarker for Anti-PD-L1 therapy response in the SCLC-I subtype

Abstract Background Advances in molecular subtype classification have improved the understanding of extensive-stage small cell lung cancer (ES-SCLC). However, immune landscape differences across ES-SCLC subtypes remain poorly defined. This study aimed to characterize ES-SCLC immune profiles and expl...

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Main Authors: Jingjing Qu, Wenjia Sun, Yuekang Li, Ziwan Cai, Binggen Wu, Qian Shen, Lijun Chen, Bo Wang, Lixiong Ying, Chenchai Xie, Jing Zheng, Jianya Zhou, Jianying Zhou
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
SCLC molecular subtypes
CD161+CD127+CD8+ T cells
Immune profiling
Survival outcome
CyTOF
Online Access:https://doi.org/10.1186/s12967-025-06724-8
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https://doi.org/10.1186/s12967-025-06724-8

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