Evaluation of Violacein Metabolic Stability and Metabolite Identification in Human, Mouse, and Rat Liver Microsomes

Evaluation of Violacein Metabolic Stability and Metabolite Identification in Human, Mouse, and Rat Liver Microsomes

<b>Background</b>: Malaria significantly impacts the health of populations living in poverty and vulnerable conditions. Resistance to current antimalarial drugs remains a major challenge and highlights the urgent need for novel, effective, and safer therapies. Violacein, a purple pigment...

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Main Authors: Debora Bressanim de Aquino Calemi, Alexandre Barcia Godoi, Giulia Minuti, Fausto Carnevale Neto, Gabriel Felipe Hispagnol, Alan Cesar Pilon, Jose Luiz Costa, Stephen Hyslop, Natalicia de Jesus Antunes
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceutics
Subjects:
ADME
drug development
liver microsomes
malaria
mass spectrometry
metabolic stability
Online Access:https://www.mdpi.com/1999-4923/17/5/601
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