Pilot-scale process development for recombinant adeno-associated virus (rAAV) production based on high-density Sf9 cell culture

Abstract Background In recent years, gene therapy drugs have been widely marketed, and their effectiveness and potential have been confirmed. Thus, increasing their production on an industrial scale is critical. Recombinant adeno-associated viruses (rAAVs) are optimal vectors for gene therapy applic...

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Bibliographic Details
Main Authors: Xinran Li, Jieyi Gu, Haoquan Wu, Yuanyuan Xie
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Virology Journal
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Online Access:https://doi.org/10.1186/s12985-024-02550-4
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