Differentiation between bipolar disorder and major depressive disorder based on AMPA receptor distribution

Differentiation between bipolar disorder and major depressive disorder based on AMPA receptor distribution

An accurate diagnostic method using biological indicators is critically needed for bipolar disorder (BD) and major depressive disorder (MDD). The excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is a crucial regulator of synaptic function, and its dysregulat...

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Main Authors: Sakiko Tsugawa, Yuichi Kimura, Junichi Chikazoe, Hiroki Abe, Tetsu Arisawa, Mai Hatano, Waki Nakajima, Hiroyuki Uchida, Tomoyuki Miyazaki, Yuuki Takada, Akane Sano, Kotaro Nakano, Tsuyoshi Eiro, Akira Suda, Takeshi Asami, Akitoyo Hishimoto, Hideaki Tani, Nobuhiro Nagai, Teruki Koizumi, Shinichiro Nakajima, Shunya Kurokawa, Yohei Ohtani, Kie Takahashi, Yuhei Kikuchi, Taisuke Yatomi, Ryo Mitoma, Shunsuke Tamura, Shingo Baba, Osamu Togao, Yoji Hirano, Hirotaka Kosaka, Hidehiko Okazawa, Masaru Mimura, Takuya Takahashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Neural Circuits
Subjects:
AMPA receptor
bipolar disorder
depression
differentiation
machine learning
Online Access:https://www.frontiersin.org/articles/10.3389/fncir.2025.1624179/full
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https://www.frontiersin.org/articles/10.3389/fncir.2025.1624179/full

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