Generation of phenotypically stable and functionally mature human bone marrow MSCs derived Schwann cells via the induction of human iPSCs-derived sensory neurons

Generation of phenotypically stable and functionally mature human bone marrow MSCs derived Schwann cells via the induction of human iPSCs-derived sensory neurons

Abstract Background Phenotypically unstable Schwann cell-like cells (SCLCs), derived from mesenchymal stem cells (MSCs) require intercellular contact-mediated cues for Schwann cell (SCs)-fate commitment. Although rat dorsal root ganglion (DRG) neurons provide contact-mediated signals for the convers...

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Bibliographic Details
Main Authors: Yu Pan, Haohui Lin, Manhon Chung, Yi Yang, Li Zhang, Xiaohua Pan, Sa Cai
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Stem Cell Research & Therapy
Subjects:
Human induced pluripotent stem cells
Human bone marrow mesenchymal stem cells
Sensory neurons
Fate commitment
Schwann cells
Myelination
Online Access:https://doi.org/10.1186/s13287-025-04217-5
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https://doi.org/10.1186/s13287-025-04217-5

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