Oleic Acid Dissolves cGAS–DNA Phase Separation to Inhibit Immune Surveillance

Oleic Acid Dissolves cGAS–DNA Phase Separation to Inhibit Immune Surveillance

Abstract Phase separation (PS) is a fundamental principle in diverse life processes including immunosurveillance. Despite numerous studies on PS, little is known about its dissolution. Here, it is shown that oleic acid (OA) dissolves the cyclic GMP–AMP synthase (cGAS)–deoxyribonucleic acid (DNA) PS...

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Bibliographic Details
Main Authors: Lina Wang, Qiaoling Liu, Na Wang, Siru Li, Wei Bian, Zhen Sun, Lulu Wang, Li Wang, Caigang Liu, Chengli Song, Quentin Liu, Qingkai Yang
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Advanced Science
Subjects:
cancer
cGAS
DNA‐sensing
phase separation
Online Access:https://doi.org/10.1002/advs.202206820
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https://doi.org/10.1002/advs.202206820

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