The clinical utility of circulating human papillomavirus across squamous cell carcinomas
Background and purpose: The similarities in biology, treatment regimens and outcome between the different human papillomavirus (HPV) associated squamous cell carcinomas (SCCs) allow for extrapolation of results generated from one SC tumor type to another. In HPV associated cancers, HPV is integrate...
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2025-01-01
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| Series: | Acta Oncologica |
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| Online Access: | https://medicaljournalssweden.se/actaoncologica/article/view/41288 |
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| author | Karen-Lise G. Spindler Anne V. Jakobsen Jesper G. Eriksen Lars Fokdal Marianne Nordsmark Lise B. J. Thorsen Karen L. Wind Anna C. Lefevre Jens Overgaard |
| author_facet | Karen-Lise G. Spindler Anne V. Jakobsen Jesper G. Eriksen Lars Fokdal Marianne Nordsmark Lise B. J. Thorsen Karen L. Wind Anna C. Lefevre Jens Overgaard |
| author_sort | Karen-Lise G. Spindler |
| collection | DOAJ |
| description | Background and purpose: The similarities in biology, treatment regimens and outcome between the different human papillomavirus (HPV) associated squamous cell carcinomas (SCCs) allow for extrapolation of results generated from one SC tumor type to another.
In HPV associated cancers, HPV is integrated into the tumor genome and can consequently be detected in the circulating fragments of the tumor DNA. Thus, measurement of HPV in the plasma is a surrogate for circulating tumor DNA (ctDNA) and holds promise as a clinically relevant biomarker in HPV associated cancers.
With the present overview we aim to present the status of circulating HPV studies in SCCs, the clinical potential and the gaps of knowledge, with the overall aim to facilitate the next steps into clinically relevant prospective trials.
Material and methods: We reviewed the literature and presented the data for each tumor type as well as analyses of the clinical utility across the SCC.
Results and interpretation: A total of 41 studies were identified in cervical, head and neck and anal SCC and we discuss the common signals from the results across the different tumor sites. Our results not only confirm the strong clinical potential but also emphasize an urgent need to coordinate studies to allow for relevant sample sizes and statistical validations.
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| format | Article |
| id | doaj-art-de816c4afe9c4843bec8e31c8f65e8d4 |
| institution | Kabale University |
| issn | 1651-226X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Oncologica |
| spelling | doaj-art-de816c4afe9c4843bec8e31c8f65e8d42025-01-03T07:44:44ZengMedical Journals SwedenActa Oncologica1651-226X2025-01-016410.2340/1651-226X.2025.41288The clinical utility of circulating human papillomavirus across squamous cell carcinomasKaren-Lise G. Spindler0Anne V. Jakobsen1Jesper G. Eriksen2Lars Fokdal3Marianne Nordsmark4Lise B. J. Thorsen5Karen L. Wind6Anna C. Lefevre7Jens Overgaard8Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, DenmarkDepartment of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, DenmarkDepartment of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, DenmarkDepartment of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Oncology, Vejle Hospital, Vejle, DenmarkDepartment of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, DenmarkDepartment of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, DenmarkDepartment of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, DenmarkDepartment of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, DenmarkDepartment of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, DenmarkBackground and purpose: The similarities in biology, treatment regimens and outcome between the different human papillomavirus (HPV) associated squamous cell carcinomas (SCCs) allow for extrapolation of results generated from one SC tumor type to another. In HPV associated cancers, HPV is integrated into the tumor genome and can consequently be detected in the circulating fragments of the tumor DNA. Thus, measurement of HPV in the plasma is a surrogate for circulating tumor DNA (ctDNA) and holds promise as a clinically relevant biomarker in HPV associated cancers. With the present overview we aim to present the status of circulating HPV studies in SCCs, the clinical potential and the gaps of knowledge, with the overall aim to facilitate the next steps into clinically relevant prospective trials. Material and methods: We reviewed the literature and presented the data for each tumor type as well as analyses of the clinical utility across the SCC. Results and interpretation: A total of 41 studies were identified in cervical, head and neck and anal SCC and we discuss the common signals from the results across the different tumor sites. Our results not only confirm the strong clinical potential but also emphasize an urgent need to coordinate studies to allow for relevant sample sizes and statistical validations. https://medicaljournalssweden.se/actaoncologica/article/view/41288squamous cell carcinomacirculating tumor DNAHuman papilloma virus |
| spellingShingle | Karen-Lise G. Spindler Anne V. Jakobsen Jesper G. Eriksen Lars Fokdal Marianne Nordsmark Lise B. J. Thorsen Karen L. Wind Anna C. Lefevre Jens Overgaard The clinical utility of circulating human papillomavirus across squamous cell carcinomas Acta Oncologica squamous cell carcinoma circulating tumor DNA Human papilloma virus |
| title | The clinical utility of circulating human papillomavirus across squamous cell carcinomas |
| title_full | The clinical utility of circulating human papillomavirus across squamous cell carcinomas |
| title_fullStr | The clinical utility of circulating human papillomavirus across squamous cell carcinomas |
| title_full_unstemmed | The clinical utility of circulating human papillomavirus across squamous cell carcinomas |
| title_short | The clinical utility of circulating human papillomavirus across squamous cell carcinomas |
| title_sort | clinical utility of circulating human papillomavirus across squamous cell carcinomas |
| topic | squamous cell carcinoma circulating tumor DNA Human papilloma virus |
| url | https://medicaljournalssweden.se/actaoncologica/article/view/41288 |
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