APPLICATION OF DEVICES FOR SPACE-RESOLVED SPECTROSCOPY ON THE EXAMPLE OF TWO-LAYER PHANTOMS CONTAINING METALLIC NANOPARTICLES
The abilities of the optical probe for fluorescence-guided stereotactic biopsy were investigated by means of a multifiber probe under 532 or 632.8 nm excitation. The set of multilayered phantoms representing a border between normal brain-tissue and a tumor with photosensitizer and gold nanoparticles...
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| Format: | Article |
| Language: | Russian |
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Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2018-06-01
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| Series: | Biomedical Photonics |
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| Online Access: | https://www.pdt-journal.com/jour/article/view/231 |
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| author | M. N. Kholodtsova P. V. Grachev W. C. Blondel P. V. Zelenkov A. A. Potapov I. A. Shcherbakov V. B. Loschenov |
| author_facet | M. N. Kholodtsova P. V. Grachev W. C. Blondel P. V. Zelenkov A. A. Potapov I. A. Shcherbakov V. B. Loschenov |
| author_sort | M. N. Kholodtsova |
| collection | DOAJ |
| description | The abilities of the optical probe for fluorescence-guided stereotactic biopsy were investigated by means of a multifiber probe under 532 or 632.8 nm excitation. The set of multilayered phantoms representing a border between normal brain-tissue and a tumor with photosensitizer and gold nanoparticles (spheres or stars) in different concentrations were made to investigate the macroscopic parameters observed during the neurosurgical biopsy sample collection by means of the optical probe. These investigantions will allow to define the border of a brain tumor and control the type of tissue being collected by a stereotactic cannula during surgery. The impact of gold nanospheres and gold nanostars added in different concentrations to the bottom-layer of phantom was analyzed by fluorescence quenching or enhancement due to energy transfer between nanoparticles and fluorescent molecules. The results allow determining the tumor border and to make the biopsy uptake more efficient by observing the character of signal change while penetrating a tumor and while going out of it. |
| format | Article |
| id | doaj-art-de7fdc4d5ed54272a836f00b4e20bb5d |
| institution | Kabale University |
| issn | 2413-9432 |
| language | Russian |
| publishDate | 2018-06-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj-art-de7fdc4d5ed54272a836f00b4e20bb5d2025-08-20T04:00:13ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322018-06-017241210.24931/2413-9432-2018-7-2-4-12137APPLICATION OF DEVICES FOR SPACE-RESOLVED SPECTROSCOPY ON THE EXAMPLE OF TWO-LAYER PHANTOMS CONTAINING METALLIC NANOPARTICLESM. N. Kholodtsova0P. V. Grachev1W. C. Blondel2P. V. Zelenkov3A. A. Potapov4I. A. Shcherbakov5V. B. Loschenov6Prokhorov General Physics Institute of the Russian Academy of Sciences; University of Lorraine; CRANProkhorov General Physics Institute of the Russian Academy of Sciences;University of Lorraine; CRANN.N. Burdenko National Scientific and Practical Center for NeurosurgeryN.N. Burdenko National Scientific and Practical Center for NeurosurgeryProkhorov General Physics Institute of the Russian Academy of SciencesProkhorov General Physics Institute of the Russian Academy of Sciences; National Research Nuclear University MEPhIThe abilities of the optical probe for fluorescence-guided stereotactic biopsy were investigated by means of a multifiber probe under 532 or 632.8 nm excitation. The set of multilayered phantoms representing a border between normal brain-tissue and a tumor with photosensitizer and gold nanoparticles (spheres or stars) in different concentrations were made to investigate the macroscopic parameters observed during the neurosurgical biopsy sample collection by means of the optical probe. These investigantions will allow to define the border of a brain tumor and control the type of tissue being collected by a stereotactic cannula during surgery. The impact of gold nanospheres and gold nanostars added in different concentrations to the bottom-layer of phantom was analyzed by fluorescence quenching or enhancement due to energy transfer between nanoparticles and fluorescent molecules. The results allow determining the tumor border and to make the biopsy uptake more efficient by observing the character of signal change while penetrating a tumor and while going out of it.https://www.pdt-journal.com/jour/article/view/231plasmon resonancemetal nanoparticlesoptical probing depthfluorescence probing depthglial tumoursbiological tissuemulti-layered tissuespatially resolved spectroscopy5-aminolevulinic acidprotoporphyrin ixstereotactic biopsyfluorescence spectroscopy |
| spellingShingle | M. N. Kholodtsova P. V. Grachev W. C. Blondel P. V. Zelenkov A. A. Potapov I. A. Shcherbakov V. B. Loschenov APPLICATION OF DEVICES FOR SPACE-RESOLVED SPECTROSCOPY ON THE EXAMPLE OF TWO-LAYER PHANTOMS CONTAINING METALLIC NANOPARTICLES Biomedical Photonics plasmon resonance metal nanoparticles optical probing depth fluorescence probing depth glial tumours biological tissue multi-layered tissue spatially resolved spectroscopy 5-aminolevulinic acid protoporphyrin ix stereotactic biopsy fluorescence spectroscopy |
| title | APPLICATION OF DEVICES FOR SPACE-RESOLVED SPECTROSCOPY ON THE EXAMPLE OF TWO-LAYER PHANTOMS CONTAINING METALLIC NANOPARTICLES |
| title_full | APPLICATION OF DEVICES FOR SPACE-RESOLVED SPECTROSCOPY ON THE EXAMPLE OF TWO-LAYER PHANTOMS CONTAINING METALLIC NANOPARTICLES |
| title_fullStr | APPLICATION OF DEVICES FOR SPACE-RESOLVED SPECTROSCOPY ON THE EXAMPLE OF TWO-LAYER PHANTOMS CONTAINING METALLIC NANOPARTICLES |
| title_full_unstemmed | APPLICATION OF DEVICES FOR SPACE-RESOLVED SPECTROSCOPY ON THE EXAMPLE OF TWO-LAYER PHANTOMS CONTAINING METALLIC NANOPARTICLES |
| title_short | APPLICATION OF DEVICES FOR SPACE-RESOLVED SPECTROSCOPY ON THE EXAMPLE OF TWO-LAYER PHANTOMS CONTAINING METALLIC NANOPARTICLES |
| title_sort | application of devices for space resolved spectroscopy on the example of two layer phantoms containing metallic nanoparticles |
| topic | plasmon resonance metal nanoparticles optical probing depth fluorescence probing depth glial tumours biological tissue multi-layered tissue spatially resolved spectroscopy 5-aminolevulinic acid protoporphyrin ix stereotactic biopsy fluorescence spectroscopy |
| url | https://www.pdt-journal.com/jour/article/view/231 |
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