Parkinson's Disease Polygenic Risk Score and Neurological Involvement in Carriers of the FMR1 Premutation Allele: A Case for Genetic Modifier

Parkinson's Disease Polygenic Risk Score and Neurological Involvement in Carriers of the FMR1 Premutation Allele: A Case for Genetic Modifier

ABSTRACT Background Premutation alleles of the FMR1 X‐linked gene containing CGG repeat expansions ranging from 55 to 200 are associated with diverse late‐onset neurological involvements, including most severe disorder termed Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS). It is intriguing that...

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Bibliographic Details
Main Authors: Danuta Z. Loesch, Freddy Chafota, Minh Q. Bui, Elsdon Storey, Anna Atkinson, Nicholas G. Martin, Scott D. Gordon, Miguel E. Rentería, Randi J. Hagerman, Flora Tassone
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
FMR1/CGG repeats
fragile X premutation
FXTAS
neurological status
Parkinson's risk score
premutation carriers
Online Access:https://doi.org/10.1002/mgg3.70043
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https://doi.org/10.1002/mgg3.70043

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