The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense.

Trypanosoma brucei gambiense causes 97% of all cases of African sleeping sickness, a fatal disease of sub-Saharan Africa. Most species of trypanosome, such as T. b. brucei, are unable to infect humans due to the trypanolytic serum protein apolipoprotein-L1 (APOL1) delivered via two trypanosome lytic...

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Bibliographic Details
Main Authors: Paul Capewell, Caroline Clucas, Eric DeJesus, Rudo Kieft, Stephen Hajduk, Nicola Veitch, Pieter C Steketee, Anneli Cooper, William Weir, Annette MacLeod
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1003686
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