Chemotherapy-induced peripheral neuropathy and its determinants among adult cancer patients on chemotherapy in northwest Ethiopia oncology centers, 2022
IntroductionPeripheral neuropathy is a nerve disorder that causes pain, numbness, and tingling in different parts of the body. It is a major and common clinical problem associated with several chemotherapeutic medications frequently used in cancer treatment, with prevalence rates ranging from 19% to...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1420518/full |
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| author | Tesfaye Engdaw Habtie Melsew Dagne Abate Gebremeskel Kibret Abebe Zenaw Tessema Wolie Addis Wondmagegn Alamaw Haymanot Zeleke Mitiku |
| author_facet | Tesfaye Engdaw Habtie Melsew Dagne Abate Gebremeskel Kibret Abebe Zenaw Tessema Wolie Addis Wondmagegn Alamaw Haymanot Zeleke Mitiku |
| author_sort | Tesfaye Engdaw Habtie |
| collection | DOAJ |
| description | IntroductionPeripheral neuropathy is a nerve disorder that causes pain, numbness, and tingling in different parts of the body. It is a major and common clinical problem associated with several chemotherapeutic medications frequently used in cancer treatment, with prevalence rates ranging from 19% to 85%. To the best of the authors’ knowledge, there is a lack of data on the magnitude and determinants of chemotherapy-induced peripheral neuropathy in Ethiopia.ObjectiveThis study aimed to assess the magnitude and associated factors of chemotherapy-induced peripheral neuropathy among adult cancer patients undergoing chemotherapy in northwest Ethiopia oncology centers in 2022.MethodAn institutional-based cross-sectional study was conducted on 406 eligible adult cancer patients undergoing chemotherapy in northwest Ethiopia oncology centers, between May and July 2022.ResultsOut of 406 adult cancer patients included in the study, 54.4% had peripheral neuropathy. The stage of cancer (AOR = 4.36 [95% CI: 1.76; 10.8]), comorbidity (AOR = 2.74 [95% CI: 1.28; 5.83]), drug regimen (AOR = 2.99 [95% CI: 1.36; 6.54]), and cycle of therapy (AOR = 4.00 [CI: 1.67; 9.65]) were significantly associated with the magnitude of chemotherapy-induced peripheral neuropathy.ConclusionChemotherapy-induced peripheral neuropathy is a common adverse event among Ethiopian cancer patients treated with various chemotherapeutic drugs. Therefore, it is necessary to establish more effective diagnostic methods and incorporate validated assessment tools, such as the European Organization for Research and Treatment of Cancer tools, either alone or in combination with other clinical instruments, into the routine evaluation of all patients receiving chemotherapeutic drug. |
| format | Article |
| id | doaj-art-dda65c8f1acf40b8900d2518d1aeac1e |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-dda65c8f1acf40b8900d2518d1aeac1e2024-12-10T06:34:07ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-12-011410.3389/fonc.2024.14205181420518Chemotherapy-induced peripheral neuropathy and its determinants among adult cancer patients on chemotherapy in northwest Ethiopia oncology centers, 2022Tesfaye Engdaw Habtie0Melsew Dagne Abate1Gebremeskel Kibret Abebe2Zenaw Tessema Wolie3Addis Wondmagegn Alamaw4Haymanot Zeleke Mitiku5Department of Nursing, College of Health Sciences, Woldia University, Woldia, EthiopiaDepartment of Adult Health Nursing, College of Health Sciences, Injibara University, Injibara, EthiopiaDepartment of Emergency and Critical Care Nursing, School of Nursing, College of Health Sciences, Woldia University, Woldia, EthiopiaDepartment of Pharmacology, College of Health Sciences, Debre Markos University, Debre Markos, EthiopiaDepartment of Nursing, College of Health Sciences, Woldia University, Woldia, EthiopiaNursing Department, College of Health Sciences, Debre Markos University, Debre Markos, EthiopiaIntroductionPeripheral neuropathy is a nerve disorder that causes pain, numbness, and tingling in different parts of the body. It is a major and common clinical problem associated with several chemotherapeutic medications frequently used in cancer treatment, with prevalence rates ranging from 19% to 85%. To the best of the authors’ knowledge, there is a lack of data on the magnitude and determinants of chemotherapy-induced peripheral neuropathy in Ethiopia.ObjectiveThis study aimed to assess the magnitude and associated factors of chemotherapy-induced peripheral neuropathy among adult cancer patients undergoing chemotherapy in northwest Ethiopia oncology centers in 2022.MethodAn institutional-based cross-sectional study was conducted on 406 eligible adult cancer patients undergoing chemotherapy in northwest Ethiopia oncology centers, between May and July 2022.ResultsOut of 406 adult cancer patients included in the study, 54.4% had peripheral neuropathy. The stage of cancer (AOR = 4.36 [95% CI: 1.76; 10.8]), comorbidity (AOR = 2.74 [95% CI: 1.28; 5.83]), drug regimen (AOR = 2.99 [95% CI: 1.36; 6.54]), and cycle of therapy (AOR = 4.00 [CI: 1.67; 9.65]) were significantly associated with the magnitude of chemotherapy-induced peripheral neuropathy.ConclusionChemotherapy-induced peripheral neuropathy is a common adverse event among Ethiopian cancer patients treated with various chemotherapeutic drugs. Therefore, it is necessary to establish more effective diagnostic methods and incorporate validated assessment tools, such as the European Organization for Research and Treatment of Cancer tools, either alone or in combination with other clinical instruments, into the routine evaluation of all patients receiving chemotherapeutic drug.https://www.frontiersin.org/articles/10.3389/fonc.2024.1420518/fullcancerchemotherapyEthiopiaperipheral neuropathyrisk factors |
| spellingShingle | Tesfaye Engdaw Habtie Melsew Dagne Abate Gebremeskel Kibret Abebe Zenaw Tessema Wolie Addis Wondmagegn Alamaw Haymanot Zeleke Mitiku Chemotherapy-induced peripheral neuropathy and its determinants among adult cancer patients on chemotherapy in northwest Ethiopia oncology centers, 2022 Frontiers in Oncology cancer chemotherapy Ethiopia peripheral neuropathy risk factors |
| title | Chemotherapy-induced peripheral neuropathy and its determinants among adult cancer patients on chemotherapy in northwest Ethiopia oncology centers, 2022 |
| title_full | Chemotherapy-induced peripheral neuropathy and its determinants among adult cancer patients on chemotherapy in northwest Ethiopia oncology centers, 2022 |
| title_fullStr | Chemotherapy-induced peripheral neuropathy and its determinants among adult cancer patients on chemotherapy in northwest Ethiopia oncology centers, 2022 |
| title_full_unstemmed | Chemotherapy-induced peripheral neuropathy and its determinants among adult cancer patients on chemotherapy in northwest Ethiopia oncology centers, 2022 |
| title_short | Chemotherapy-induced peripheral neuropathy and its determinants among adult cancer patients on chemotherapy in northwest Ethiopia oncology centers, 2022 |
| title_sort | chemotherapy induced peripheral neuropathy and its determinants among adult cancer patients on chemotherapy in northwest ethiopia oncology centers 2022 |
| topic | cancer chemotherapy Ethiopia peripheral neuropathy risk factors |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1420518/full |
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