Codeine 3-O-demethylase catalyzed biotransformation of morphinan alkaloids in Escherichia coli: site directed mutagenesis of terminal residues improves enzyme expression, stability and biotransformation yield

Codeine 3-O-demethylase catalyzed biotransformation of morphinan alkaloids in Escherichia coli: site directed mutagenesis of terminal residues improves enzyme expression, stability and biotransformation yield

Abstract The cultivation of opium poppy is the only commercially viable source of most morphinan alkaloids. Bioproduction of morphinan alkaloids in recombinant whole-cell systems provides a promising alternate source of these valuable compounds. The enzyme codeine 3-O-demethylase can transform morph...

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Bibliographic Details
Main Authors: Garrick W. K. Spencer, Xu Li, Kenny W. L. Lam, George Mutch, Fiona H. Fry, Sally L. Gras
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Biological Engineering
Subjects:
Poppy
E.coli
Bioconversion
Oripavine
Morphine
DDmut.
Online Access:https://doi.org/10.1186/s13036-025-00477-0
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