Oral administration of pyrophosphate inhibits connective tissue calcification

Oral administration of pyrophosphate inhibits connective tissue calcification

Abstract Various disorders including pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI), which are caused by inactivating mutations in ABCC6 and ENPP1, respectively, present with extensive tissue calcification due to reduced plasma pyrophosphate (PPi). However, i...

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Main Authors: Dóra Dedinszki, Flóra Szeri, Eszter Kozák, Viola Pomozi, Natália Tőkési, Tamás Róbert Mezei, Kinga Merczel, Emmanuel Letavernier, Ellie Tang, Olivier Le Saux, Tamás Arányi, Koen van de Wetering, András Váradi
Format: Article
Language:English
Published: Springer Nature 2017-07-01
Series:EMBO Molecular Medicine
Subjects:
generalized arterial calcification of infancy
oral pyrophosphate treatment
pseudoxanthoma elasticum
soft tissue calcification
Online Access:https://doi.org/10.15252/emmm.201707532
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https://doi.org/10.15252/emmm.201707532

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