Penicillium-Derived Inhibitors of Plasmodium falciparum Lactate Dehydrogenase (PfLDH): A Computational Approach for Novel Antimalarial Therapy Development

Penicillium-Derived Inhibitors of Plasmodium falciparum Lactate Dehydrogenase (PfLDH): A Computational Approach for Novel Antimalarial Therapy Development

Malaria remains a major global health challenge, necessitating the discovery of novel therapeutic agents. This study investigates secondary metabolites from Penicillium spp. as potential inhibitors of Plasmodium falciparum lactate dehydrogenase (PfLDH), a critical enzyme in the parasite’s glycolytic...

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Main Authors: Imran Sama-ae, Pimthip Muengthongon, Azeezah Tohlaeh, Watcharaphon Rukhachan, Pawika Kiattikul, Fathiyah Samaeng, Aritsara Mitklin, Md. Atiar Rahman, Aman Tedasen, Pattamaporn Kwankaew, Manas Kotepui, Anirut Kepan
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Scientifica
Online Access:http://dx.doi.org/10.1155/sci5/8838031
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http://dx.doi.org/10.1155/sci5/8838031

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