Inhibition of CDK5 signaling mediated inflammation in macrophages promotes cutaneous wound healing

Inhibition of CDK5 signaling mediated inflammation in macrophages promotes cutaneous wound healing

Abstract Cyclin-dependent kinase 5 (CDK5) plays a critical role in the inflammatory response. Macrophages are pivotal orchestrators of inflammation, fibrosis, and wound repair. However, the effectiveness of CDK5 in macrophages on cutaneous wound healing remains inadequately characterized. We determi...

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Main Authors: Jingjing Wang, Lin Ji, Yingbo Gao, Jingyu Sun, Xiaobin Zhou, Yujia Ding, Zihan Zhou, Xiaofan Guo, Chao Liu, Yujie Wang, Qingfu Zhang, Zhenmu Lv, Dong Ma
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Cutaneous wound healing
Cyclin-dependent protein kinase 5
Macrophages
Phenotypic transformation
Silent information regulator Sirtuin 1
Online Access:https://doi.org/10.1038/s41598-025-02488-9
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https://doi.org/10.1038/s41598-025-02488-9

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