PKR associates with 4.1R to promote anchorage-independent growth of hepatocellular carcinoma and lead to poor prognosis

PKR associates with 4.1R to promote anchorage-independent growth of hepatocellular carcinoma and lead to poor prognosis

Abstract RNA-dependent protein kinase (PKR) may have a positive regulatory role in controlling tumor growth and progression in hepatocellular carcinoma (HCC). However, the downstream substrates and the molecular mechanism of PKR in the growth and progression of HCC have not been clarified. In this s...

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Main Authors: Yusuke Okujima, Takao Watanabe, Takeshi Ito, Yasumichi Inoue, Yutaka Kasai, Yusuke Imai, Yoshiko Nakamura, Mitsuhito Koizumi, Osamu Yoshida, Yoshio Tokumoto, Masashi Hirooka, Masanori Abe, Ryosuke Kawakami, Takashi Saitou, Takeshi Imamura, Yoshinori Murakami, Yoichi Hiasa
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
eIF-2 kinase
Erythrocyte membrane band 4.1 protein
Liver neoplasms
Cell line
Prognosis
Online Access:https://doi.org/10.1038/s41598-024-75142-5
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https://doi.org/10.1038/s41598-024-75142-5

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