Some pharmacogenetic aspects of the <i>ABCB1</i> gene in lopinavir / ritonavir concentration variability in children with HIV infection: A pilot study

Some pharmacogenetic aspects of the <i>ABCB1</i> gene in lopinavir / ritonavir concentration variability in children with HIV infection: A pilot study

Polymorphic variants of the multidrug resistance gene (ABCB1 or MDR1) are associated with changes in the absorption and transport of drugs in the body. One of the substrates of the ABCB1 transporter is an antiretroviral drug from the class of protease inhibitors, lopinavir.   The aim. To research th...

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Bibliographic Details
Main Authors: A. Yu. Sambyalova, T. A. Bairova, T. L. Manaenkova, A. V. Belskikh, E. V. Belyaeva, O. A. Ershova, D. V. Kumratov, A. I. Paramonov, Yu. K. Plotnikova, L. V. Kolomeets, L. V. Rychkova
Format: Article
Language:Russian
Published: Scientific Сentre for Family Health and Human Reproduction Problems 2022-12-01
Series:Acta Biomedica Scientifica
Subjects:
antiretroviral therapy
hiv infection
polymorphic variants
pharmacogenetics
Online Access:https://www.actabiomedica.ru/jour/article/view/3801
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