Assessment and outcome of hospitalized patients during delta variant COVID-19 pandemic: A multicenter international study
Introduction: To date, the world has experienced four waves of the Coronavirus disease- 19 (COVID-19) pandemic. Patients infected during the era of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant were the subject of this study. The objectives were to describe their clinic...
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The Journal of Infection in Developing Countries
2022-11-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/16696 |
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| author | Fatma Abdelaziz Amer Maysaa Abdallah Saeed Shaker Wagih Shaltout Hanaa Abu Elazayem Nofal Ramadan Mahmoud Nafae Kadem Arslan Alpaslan Tanoglu Mihai Nechifor Catalina Luca Zaid Hashim Ali Al-kadhim Ahmed Mosallem Noha Mohammed Hammad |
| author_facet | Fatma Abdelaziz Amer Maysaa Abdallah Saeed Shaker Wagih Shaltout Hanaa Abu Elazayem Nofal Ramadan Mahmoud Nafae Kadem Arslan Alpaslan Tanoglu Mihai Nechifor Catalina Luca Zaid Hashim Ali Al-kadhim Ahmed Mosallem Noha Mohammed Hammad |
| author_sort | Fatma Abdelaziz Amer |
| collection | DOAJ |
| description |
Introduction: To date, the world has experienced four waves of the Coronavirus disease- 19 (COVID-19) pandemic. Patients infected during the era of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant were the subject of this study. The objectives were to describe their clinical manifestations, explain their laboratory and radiological findings, conclude factors contributing to clinical outcomes, and evaluate treatment protocols.
Methodology: Relevant data were collected retrospectively from records of patients admitted to six referral centers in four countries. Data included sociodemographic patterns, symptoms, associated comorbidities, physical examination, laboratory and radiologic findings, treatment received, and patient outcomes.
Results: Data analysis identified symptomatology and variables related to acquisition and infection outcome. The most prevalent symptoms were cough (81.5%), body aches (74.1%), and fever (71.6%). Independent risk factors for mortality were age, vomiting, epigastric pain, diabetes, obesity, oxygen saturation less than 90%, leukocytosis, neutrophilia, lymphopenia, thrombocytopenia, elevated creatinine, high glucose level, lung ground glass opacities with consolidation, affection of four lobes and bilateralism. Neither d-dimer nor lactate dehydrogenase nor ferritin foretells death possibility. The efficacy of the medications used was convenient.
Conclusions: Assessing the clinical features of different COVID-19 waves, identifying predictors of outcomes, and concluding the efficacy of treatment protocols provide insight into patients’ responses and viral behaviors, which help in the proper diagnosis and treatment of subsequent surges.
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| format | Article |
| id | doaj-art-dd24637f1ed24f91a1a4a583ba2f3f07 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-dd24637f1ed24f91a1a4a583ba2f3f072025-08-20T03:52:39ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802022-11-01161110.3855/jidc.16696Assessment and outcome of hospitalized patients during delta variant COVID-19 pandemic: A multicenter international studyFatma Abdelaziz Amer0Maysaa Abdallah Saeed1Shaker Wagih Shaltout2Hanaa Abu Elazayem Nofal3Ramadan Mahmoud Nafae4Kadem Arslan5Alpaslan Tanoglu6Mihai Nechifor7Catalina Luca8Zaid Hashim Ali Al-kadhim9Ahmed Mosallem10Noha Mohammed Hammad11Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, EgyptViral Infection Working Group of International Society of Antimicrobial Chemotherapy VIWG/ISACDepartment of Tropical Medicine, Port Said University, Port Said, EgyptDepartment of Public Health and Preventive Medicine, Faculty of Medicine, Zagazig University, Zagazig, EgyptDepartment of Pulmonary Medicine, Zagazig Faculty of Medicine, Zagazig, EgyptDepartment of Internal Medicine, Sancaktepe Sehit Prof Dr Ilhan Varank Training and Research Hospital, Istanbul, TurkeyViral Infection Working Group of International Society of Antimicrobial Chemotherapy VIWG/ISACViral Infection Working Group of International Society of Antimicrobial Chemotherapy VIWG/ISACViral Infection Working Group of International Society of Antimicrobial Chemotherapy VIWG/ISACMBChB. A.B.M. Kazemia Education Hospital, Baghdad, IraqDepartment of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Zagazig University, Zagazig, EgyptDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt Introduction: To date, the world has experienced four waves of the Coronavirus disease- 19 (COVID-19) pandemic. Patients infected during the era of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant were the subject of this study. The objectives were to describe their clinical manifestations, explain their laboratory and radiological findings, conclude factors contributing to clinical outcomes, and evaluate treatment protocols. Methodology: Relevant data were collected retrospectively from records of patients admitted to six referral centers in four countries. Data included sociodemographic patterns, symptoms, associated comorbidities, physical examination, laboratory and radiologic findings, treatment received, and patient outcomes. Results: Data analysis identified symptomatology and variables related to acquisition and infection outcome. The most prevalent symptoms were cough (81.5%), body aches (74.1%), and fever (71.6%). Independent risk factors for mortality were age, vomiting, epigastric pain, diabetes, obesity, oxygen saturation less than 90%, leukocytosis, neutrophilia, lymphopenia, thrombocytopenia, elevated creatinine, high glucose level, lung ground glass opacities with consolidation, affection of four lobes and bilateralism. Neither d-dimer nor lactate dehydrogenase nor ferritin foretells death possibility. The efficacy of the medications used was convenient. Conclusions: Assessing the clinical features of different COVID-19 waves, identifying predictors of outcomes, and concluding the efficacy of treatment protocols provide insight into patients’ responses and viral behaviors, which help in the proper diagnosis and treatment of subsequent surges. https://jidc.org/index.php/journal/article/view/16696COVID-19 pandemicoutcome predictorsSARS-COV-2 |
| spellingShingle | Fatma Abdelaziz Amer Maysaa Abdallah Saeed Shaker Wagih Shaltout Hanaa Abu Elazayem Nofal Ramadan Mahmoud Nafae Kadem Arslan Alpaslan Tanoglu Mihai Nechifor Catalina Luca Zaid Hashim Ali Al-kadhim Ahmed Mosallem Noha Mohammed Hammad Assessment and outcome of hospitalized patients during delta variant COVID-19 pandemic: A multicenter international study Journal of Infection in Developing Countries COVID-19 pandemic outcome predictors SARS-COV-2 |
| title | Assessment and outcome of hospitalized patients during delta variant COVID-19 pandemic: A multicenter international study |
| title_full | Assessment and outcome of hospitalized patients during delta variant COVID-19 pandemic: A multicenter international study |
| title_fullStr | Assessment and outcome of hospitalized patients during delta variant COVID-19 pandemic: A multicenter international study |
| title_full_unstemmed | Assessment and outcome of hospitalized patients during delta variant COVID-19 pandemic: A multicenter international study |
| title_short | Assessment and outcome of hospitalized patients during delta variant COVID-19 pandemic: A multicenter international study |
| title_sort | assessment and outcome of hospitalized patients during delta variant covid 19 pandemic a multicenter international study |
| topic | COVID-19 pandemic outcome predictors SARS-COV-2 |
| url | https://jidc.org/index.php/journal/article/view/16696 |
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