Identification of a 2-phenoxychromone derivative as a novel inhibitor of lipid droplet formation in hepatocytes and adipocytes

Identification of a 2-phenoxychromone derivative as a novel inhibitor of lipid droplet formation in hepatocytes and adipocytes

Dysregulated lipid droplet (LD) accumulation in hepatocytes increases the risk of metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease worldwide. Furthermore, excessive accumulation of LD...

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Main Authors: Yu-Tsen Hsieh, Tung-Hsuan Kang, Hsin-Yi Hung, Yi-Han Chang, Kuan-Chen Cheng, Chia-Yih Wang, Wen-Tai Chiu, Pai-Sheng Chen, Shih-Chieh Lin, I-Chen Peng
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Results in Chemistry
Subjects:
2-phenoxychromone derivative
Adipocytes
Hepatocytes
Lipid droplet
Metabolic dysfunction-associated steatotic liver disease
Obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625003728
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