CF2H-synthon enables asymmetric radical difluoroalkylation for synthesis of chiral difluoromethylated amines

CF2H-synthon enables asymmetric radical difluoroalkylation for synthesis of chiral difluoromethylated amines

Abstract The difluoromethyl group is a crucial fluorinated moiety with distinctive biological properties, and the synthesis of chiral CF₂H-containing analogs has been recognized as a powerful strategy in drug design. To date, the most established method for accessing enantioenriched difluoromethyl c...

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Bibliographic Details
Main Authors: Peng Liu, Yan He, Chen-Hui Jiang, Wei-Ran Ren, Ruo-Xing Jin, Ting Zhang, Wang-Xuan Chen, Xuan Nie, Xi-Sheng Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-55912-z
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