Predictive value of the maternal alpha-fetoprotein variant, L2, during the first trimester of pregnancy screening for fetal trisomy 21, trisomy 18, and neural tube defects

Predictive value of the maternal alpha-fetoprotein variant, L2, during the first trimester of pregnancy screening for fetal trisomy 21, trisomy 18, and neural tube defects

Abstract Background To assess the predictive usefulness of maternal serum alpha fetoprotein variant L2 (AFP-L2) for fetal trisomy 21, trisomy 18, and neural tube abnormalities (NTDs) in early pregnancy screening. Methods This retrospective case-control study including 155 fetuses diagnosed with tris...

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Bibliographic Details
Main Authors: Yiming Chen, Wenwen Ning, Caihe Wen, Linyuan Gu, Xuelian Chu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Pregnancy and Childbirth
Subjects:
Early pregnancy
Prenatal screening
Alpha-fetoprotein variant L2
Trisomy 21
Trisomy 18
Neural tube defects
Online Access:https://doi.org/10.1186/s12884-025-07893-6
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https://doi.org/10.1186/s12884-025-07893-6

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