Exosomes derived from ALR-modified adipose mesenchymal stem cells mediate hepatoprotective effects on hepatic ischemia–reperfusion injury by promoting regeneration and protecting mitochondria

Exosomes derived from ALR-modified adipose mesenchymal stem cells mediate hepatoprotective effects on hepatic ischemia–reperfusion injury by promoting regeneration and protecting mitochondria

Abstract Background Exosomes are rich in bioactive molecules. Their unique lipid bilayer structure gives them the advantages of protecting the contents from degradation, easy cellular uptake, and good passive targeting. MSC-derived exosomes, which are natural vesicles ideal for gene delivery, exhibi...

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Bibliographic Details
Main Authors: YaJun Ma, Tao Liu, Pujun Li, Lei Cao, Xiangyu Lu, HongBin Wang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Cell-free therapy
Gene therapy
ADSC-Exo
ALR
Miniature porcine
Hepatic IRI
Online Access:https://doi.org/10.1186/s13287-025-04517-w
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https://doi.org/10.1186/s13287-025-04517-w

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