Local application of sodium thiosulfate as an otoprotectant for cisplatin-exposed patients – A narrative literature review to explore the potential benefit for children with cancer

Local application of sodium thiosulfate as an otoprotectant for cisplatin-exposed patients – A narrative literature review to explore the potential benefit for children with cancer

Background: Ototoxicity is a highly prevalent, serious, and irreversible side effect in cisplatin-treated childhood cancer patients, which can significantly impact speech-language development, psychosocial development, and quality of life. In this respect, the development and implementation of relia...

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Main Authors: Nienke Streefkerk, Amirhossein Masroor, James I. Geller, Martine van Grotel, Marc Ansari, Eric Bouffet, Archie Bleyer, Brice Fresnau, Michael Sullivan, Alwin D.R. Huitema, Alexander E. Hoetink, Per Kogner, Rudolf Maibach, Allison F. O’Neill, Vassilios Papadakis, Kaukab M. Rajput, Gareth J. Veal, Penelope R. Brock, Annelot J.M. Meijer, Marry M. van den Heuvel-Eibrink
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:EJC Paediatric Oncology
Subjects:
Childhood cancer
Ototoxicity
Hearing loss
Cisplatin
Sodium thiosulfate
Online Access:http://www.sciencedirect.com/science/article/pii/S2772610X24000710
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