THE RISK OF EARLY LIVER ALLOGRAFT DYSFUNCTION IS ASSOCIATED WITH THE TLR-4 GENE GENOTYPE IN THE RS913930 SEQUENCE AND IS IMPLEMENTED VIA HMGB1 NUCLEAR PROTEIN, KUPFFER CELLS AND IL-23 ACTIVATION

THE RISK OF EARLY LIVER ALLOGRAFT DYSFUNCTION IS ASSOCIATED WITH THE TLR-4 GENE GENOTYPE IN THE RS913930 SEQUENCE AND IS IMPLEMENTED VIA HMGB1 NUCLEAR PROTEIN, KUPFFER CELLS AND IL-23 ACTIVATION

Aim. To evaluate the associations of genotypes of clinically relevant nucleotides rs11536865, rs913930 and rs5030717 of the TLR-4 gene with the risk of development and severity of early allograft dysfunction after liver transplantation. Materials and methods. A case-control study enrolling 71 patien...

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Main Authors: A. E. Shcherba, A. M. Kustanovich, A. I. Kireyeva, D. Yu. Efimov, S. V. Korotkov, A. F. Minov, O. A. Lebedz, A. A. Koritko, D. A. Fedoruk, E. O. Santotsky, A. M. Dzyadzko, O. O. Rummo
Format: Article
Language:Russian
Published: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov 2016-11-01
Series:Вестник трансплантологии и искусственных органов
Subjects:
liver transplantation
allograft dysfunction
gene polymorphism
tlr-4
kupffer cells
Online Access:https://journal.transpl.ru/vtio/article/view/668
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