A novel clinically relevant antagonistic interplay between prolactin and oncogenic YAP-CCN2 pathways as a differentiation therapeutic target in breast cancer
Abstract Cellular differentiation limits cellular plasticity allowing cells to attain their specialized functional characteristics and phenotypes, whereas loss of differentiation is a hallmark of cancer. Thus, characterizing mechanisms underlying differentiation is key to discover new cancer therape...
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| Main Authors: | Xueqing Liu, Alaa Moamer, Roger Gomes da Silva, Aidan Shoham-Amizlev, Dana Hamam, Anwar Shams, Jean-Jacques Lebrun, Suhad Ali |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-03-01
|
| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-025-07547-7 |
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