A novel clinically relevant antagonistic interplay between prolactin and oncogenic YAP-CCN2 pathways as a differentiation therapeutic target in breast cancer

Abstract Cellular differentiation limits cellular plasticity allowing cells to attain their specialized functional characteristics and phenotypes, whereas loss of differentiation is a hallmark of cancer. Thus, characterizing mechanisms underlying differentiation is key to discover new cancer therape...

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Bibliographic Details
Main Authors: Xueqing Liu, Alaa Moamer, Roger Gomes da Silva, Aidan Shoham-Amizlev, Dana Hamam, Anwar Shams, Jean-Jacques Lebrun, Suhad Ali
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07547-7
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