顺铂术前化疗对老龄大鼠术后认知功能及海马NMDA受体表达的影响
摘 要: 【目的】 探讨顺铂术前化疗对老龄大鼠术后认知功能及海马组织NMDA受体表达的影响?【方法】 健康雌性SD大鼠30只,10-12月龄,按随机数字表法,将大鼠分为两组(n = 15):生理盐水组(Normal saline injection group)和顺铂组(Cisplatin injection group)?顺铂组经腹腔注射顺铂3 mg/kg,每周1次,共3次?生理盐水组经腹腔注射等容量生理盐水?完成注射后将上述两组分别分为6组(n = 5):单纯生理盐水组(S组)?生理盐水+麻醉组(SP组)?生理盐水+麻醉+手术组(SPO组)?单纯顺铂组(C组)?顺铂+麻醉组(CP组)?顺铂...
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| Format: | Article |
|---|---|
| Language: | zho |
| Published: |
Editorial Office of Journal of Sun Yat-sen University
2016-01-01
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| Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
| Subjects: | |
| Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/43572316/ |
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