Correlation of micro-inflammatory reaction and level of omentin-1 expression with coronary heart disease in maintenance hemodialysis patients
Objective To investigate the correlation between the micro-inflammatory reaction and the level of omentin-1 expression with the presence of coronary heart disease(CHD)in maintenance hemodialysis(MHD)patients.Methods Methods A total of 70 patients with MHD were admitted into our research during June...
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Editorial Department of Journal of Clinical Nephrology
2017-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | ZHU Shi-yan CHEN Jian-quan LUO Cheng-zhi LI Dan-ni FU Ling-ling CHEN Chang-ming GAN Ping |
| author_facet | ZHU Shi-yan CHEN Jian-quan LUO Cheng-zhi LI Dan-ni FU Ling-ling CHEN Chang-ming GAN Ping |
| author_sort | ZHU Shi-yan |
| collection | DOAJ |
| description | Objective To investigate the correlation between the micro-inflammatory reaction and the level of omentin-1 expression with the presence of coronary heart disease(CHD)in maintenance hemodialysis(MHD)patients.Methods Methods A total of 70 patients with MHD were admitted into our research during June 2010 to November 2016.All the patients were divided into 2groups:CHD group(group A)(n=36)and non-CHD group(group B)(n=34).The plasma levels of high sensitivity c-reactive protein(hs-CRP),interleukin-6(IL-6),omentin-1 and other clinical markers were also measured during the first 3 days.After three times of measurements with the same techniques at different time points(the first month,the third month,and the sixth month),the average values were taken as a reference.We analyzed the change of the parameters and evaluated their correlation with the CHD.Results The hs-CRP and IL-6 levels were significantly higher(P<0.05),and ALB and Hb levels were significantly lower in group A than in group B(P<0.05).The level of SCr and BUN had no statistically significant difference between two groups(P>0.05).The level of omentin-1 in the group A(12.85±6.35 ng/mL)was significantly lower than that in the group B(18.58±7.68)ng/mL(P<0.05).Pearson correlation analysis revealed that the level of omentin-1was negatively correlated with hs-CRP and IL-6(r=-0.235,P<0.05;r=-0.186,P<0.05),and positively correlated with Alb and Hb(r=0.324,P<0.05;r=0.296,P<0.05),but not correlated with SCr and BUN(r=-0.028,P>0.05;r=-0.032,P>0.05).Logistic regression analysis showed that the increases in hs-CRP and IL-6 or the decreases in omentin-1 were the risk factors for CHD,and the Alb,Hb,SCr and BUN had no correlation with the incidence of CHD.ConclusionsThe increases in hs-CRP and IL-6 or the decrease in omentin-1 may be involved in the occurrence and development of CHD. |
| format | Article |
| id | doaj-art-dbc3e7538b8b43e49f820c33ae9ff1a8 |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2017-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
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| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-dbc3e7538b8b43e49f820c33ae9ff1a82025-08-20T02:28:51ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902017-01-0140741057916705Correlation of micro-inflammatory reaction and level of omentin-1 expression with coronary heart disease in maintenance hemodialysis patientsZHU Shi-yanCHEN Jian-quanLUO Cheng-zhiLI Dan-niFU Ling-lingCHEN Chang-mingGAN PingObjective To investigate the correlation between the micro-inflammatory reaction and the level of omentin-1 expression with the presence of coronary heart disease(CHD)in maintenance hemodialysis(MHD)patients.Methods Methods A total of 70 patients with MHD were admitted into our research during June 2010 to November 2016.All the patients were divided into 2groups:CHD group(group A)(n=36)and non-CHD group(group B)(n=34).The plasma levels of high sensitivity c-reactive protein(hs-CRP),interleukin-6(IL-6),omentin-1 and other clinical markers were also measured during the first 3 days.After three times of measurements with the same techniques at different time points(the first month,the third month,and the sixth month),the average values were taken as a reference.We analyzed the change of the parameters and evaluated their correlation with the CHD.Results The hs-CRP and IL-6 levels were significantly higher(P<0.05),and ALB and Hb levels were significantly lower in group A than in group B(P<0.05).The level of SCr and BUN had no statistically significant difference between two groups(P>0.05).The level of omentin-1 in the group A(12.85±6.35 ng/mL)was significantly lower than that in the group B(18.58±7.68)ng/mL(P<0.05).Pearson correlation analysis revealed that the level of omentin-1was negatively correlated with hs-CRP and IL-6(r=-0.235,P<0.05;r=-0.186,P<0.05),and positively correlated with Alb and Hb(r=0.324,P<0.05;r=0.296,P<0.05),but not correlated with SCr and BUN(r=-0.028,P>0.05;r=-0.032,P>0.05).Logistic regression analysis showed that the increases in hs-CRP and IL-6 or the decreases in omentin-1 were the risk factors for CHD,and the Alb,Hb,SCr and BUN had no correlation with the incidence of CHD.ConclusionsThe increases in hs-CRP and IL-6 or the decrease in omentin-1 may be involved in the occurrence and development of CHD.http://www.lcszb.com/thesisDetails?columnId=57916705&Fpath=home&index=0Maintenance hemodialysisMicro-inflammationHigh sensitive C-reactive proteinInterleukin-6Omentin-1Coronary heart disease |
| spellingShingle | ZHU Shi-yan CHEN Jian-quan LUO Cheng-zhi LI Dan-ni FU Ling-ling CHEN Chang-ming GAN Ping Correlation of micro-inflammatory reaction and level of omentin-1 expression with coronary heart disease in maintenance hemodialysis patients Linchuang shenzangbing zazhi Maintenance hemodialysis Micro-inflammation High sensitive C-reactive protein Interleukin-6 Omentin-1 Coronary heart disease |
| title | Correlation of micro-inflammatory reaction and level of omentin-1 expression with coronary heart disease in maintenance hemodialysis patients |
| title_full | Correlation of micro-inflammatory reaction and level of omentin-1 expression with coronary heart disease in maintenance hemodialysis patients |
| title_fullStr | Correlation of micro-inflammatory reaction and level of omentin-1 expression with coronary heart disease in maintenance hemodialysis patients |
| title_full_unstemmed | Correlation of micro-inflammatory reaction and level of omentin-1 expression with coronary heart disease in maintenance hemodialysis patients |
| title_short | Correlation of micro-inflammatory reaction and level of omentin-1 expression with coronary heart disease in maintenance hemodialysis patients |
| title_sort | correlation of micro inflammatory reaction and level of omentin 1 expression with coronary heart disease in maintenance hemodialysis patients |
| topic | Maintenance hemodialysis Micro-inflammation High sensitive C-reactive protein Interleukin-6 Omentin-1 Coronary heart disease |
| url | http://www.lcszb.com/thesisDetails?columnId=57916705&Fpath=home&index=0 |
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