Mutations Selectively Evolving Peroxidase Activity Among Alternative Catalytic Functions of Human Glutathione Transferase P1-1

Mutations Selectively Evolving Peroxidase Activity Among Alternative Catalytic Functions of Human Glutathione Transferase P1-1

Glutathione transferases are detoxication enzymes with broad catalytic diversity, and small alterations to the protein’s primary structure can have considerable effects on the enzyme’s substrate selectivity profile. We demonstrate that two point mutations in glutathione transferase P1-1 suffice to g...

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Bibliographic Details
Main Authors: Aram Ismail, Bengt Mannervik
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Antioxidants
Subjects:
glutathione transferases
GST P1-1
cumene hydroperoxide
mutant libraries
peroxidase activity
alternative substrates
Online Access:https://www.mdpi.com/2076-3921/13/11/1347
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