Transdifferentiation of rat keratinocyte progenitors to corneal epithelial cells by limbal niche via the STAT3/PI3K/AKT signaling pathway

Transdifferentiation of rat keratinocyte progenitors to corneal epithelial cells by limbal niche via the STAT3/PI3K/AKT signaling pathway

Abstract Purpose To develop a method for enriching keratinocyte progenitor cells (KPCs) and establish a limbal niche (LN)-mediated transdifferentiation protocol of KPCs into corneal epithelial cells. Methods Limbal niche cells (LNCs) were isolated from limbal tissues through enzymatic digestion and...

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Main Authors: Bei Wang, Jiang-Lan Zhao, Gong-Yue Wang, Wan-Ying Cai, Yu-Ting Xiao, Jia-Song Wang, Chao Wang, Yu-Zhi Li, Xi Peng, Tian-Yu Yao, Ming-Chang Zhang, Hua-Tao Xie
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Stem Cell Research & Therapy
Subjects:
 Corneal epithelial cells
Transdifferentiation
Keratinocyte progenitors
Limbal niche
STAT3
PI3K/AKT signaling pathway
Online Access:https://doi.org/10.1186/s13287-024-04129-w
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